Delmadinone acetate

Delmadinone acetate
Clinical data
ATCvet code	QG03DX91 (WHO) ;
Identifiers
	IUPAC name 6-chloro-3,20-dioxopregna-1,4,6-trien-17-yl acetate;
CAS Number	13698-49-2;
PubChem CID	10135765;
ChemSpider	8311278;
ChEMBL	ChEMBL2104598;
CompTox Dashboard (EPA)	DTXSID60160018 ;
ECHA InfoCard	100.033.821
Chemical and physical data
Formula	C23H27ClO4
Molar mass	402.911 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C\1\C=C/[C@]4(C(=C/1)C(\Cl)=C/[C@@H]2[C@@H]4CC[C@@]3([C@@](OC(=O)C)(C(=O)C)CC[C@@H]23)C)C;
	InChI InChI=1S/C23H27ClO4/c1-13(25)23(28-14(2)26)10-7-18-16-12-20(24)19-11-15(27)5-8-21(19,3)17(16)6-9-22(18,23)4/h5,8,11-12,16-18H,6-7,9-10H2,1-4H3/t16-,17+,18+,21-,22+,23+/m1/s1; Key:CGBCCZZJVKUAMX-DFXBJWIESA-N;

Delmadinone acetate (INN, USAN, BAN) (brand names Delmate, Estrex, Tardak, Tardastren, Tardastrex, Vetadinon, Zenadrex), sometimes abbreviated as DMA, and also known as 1,6-bisdehydro-6-chloro-17α-acetoxyprogesterone, is a steroidal progestin with antigonadotropic (and hence, antiandrogenic and antiestrogenic) properties which is used to treat androgen-associated conditions in veterinary medicine.^[1]^[2]^[3] It must be used with care as it has the potential to cause adrenal insufficiency via inhibition of adrenocorticotropic hormone (ACTH) secretion from the pituitary gland.^[4]

References

^ F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 579. ISBN 978-0-412-46630-4. Retrieved 30 May 2012.
^ Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 298. ISBN 978-3-88763-075-1. Retrieved 30 May 2012.
^ Ian Morton; Judith M. Hall (1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer. p. 92. ISBN 978-0-7514-0499-9. Retrieved 30 May 2012.
^ Court EA, Watson AD, Church DB, Emslie DR (August 1998). "Effects of delmadinone acetate on pituitary-adrenal function, glucose tolerance and growth hormone in male dogs". Australian Veterinary Journal. 76 (8): 555–60. doi:10.1111/j.1751-0813.1998.tb10216.x. PMID 9741725.

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