Desmoglein-3

DSG3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5EQX
Identifiers
Aliases	DSG3, CDHF6, PVA, desmoglein 3, ABOLM
External IDs	OMIM: 169615; MGI: 99499; HomoloGene: 55513; GeneCards: DSG3; OMA:DSG3 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) Band 18q12.1 Start 31,447,741 bp End 31,478,702 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18 A2|18 11.39 cM Start 20,643,331 bp End 20,680,516 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums gingival epithelium mucosa of pharynx oral cavity body of tongue human penis vulva cervix epithelium skin of thigh skin of abdomen Top expressed in esophagus skin of external ear conjunctival fornix cornea lip skin of back skin of abdomen hair follicle lumbar spinal ganglion hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding Cellular component integral component of membrane cytosol cell junction desmosome extracellular exosome membrane plasma membrane cornified envelope cell-cell junction Biological process cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules keratinization cornification cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1830 13512 Ensembl ENSG00000134757 ENSMUSG00000056632 UniProt P32926 O35902 RefSeq (mRNA) NM_001944 NM_030596 RefSeq (protein) NP_001935 NP_085099 Location (UCSC) Chr 18: 31.45 – 31.48 Mb Chr 18: 20.64 – 20.68 Mb PubMed search
Wikidata
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Desmoglein-3 is a protein that in humans is encoded by the DSG3 gene.

Function

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.

Interactions

Desmoglein 3 has been shown to interact with PKP3.

See also

• Desmoglein
• List of target antigens in pemphigus
• List of conditions caused by problems with junctional proteins

Further reading

• Amagai M, Klaus-Kovtun V, Stanley JR (1992). "Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion". Cell. 67 (5): 869–77. doi:10.1016/0092-8674(91)90360-B. PMID 1720352.
• Roh JY, Stanley JR (1995). "Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment". J. Invest. Dermatol. 104 (5): 720–4. doi:10.1111/1523-1747.ep12606963. PMID 7738346.
• Wang Y, Amagai M, Minoshima S, et al. (1994). "The human genes for desmogleins (DSG1 and DSG3) are located in a small region on chromosome 18q12". Genomics. 20 (3): 492–5. doi:10.1006/geno.1994.1207. PMID 8034325.
• Schäfer S, Koch PJ, Franke WW (1994). "Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins". Exp. Cell Res. 211 (2): 391–9. doi:10.1006/excr.1994.1103. PMID 8143788.
• Kárpáti S, Amagai M, Prussick R, et al. (1993). "Pemphigus vulgaris antigen, a desmoglein type of cadherin, is localized within keratinocyte desmosomes". J. Cell Biol. 122 (2): 409–15. doi:10.1083/jcb.122.2.409. PMC 2119642. PMID 8320263.
• Silos SA, Tamai K, Li K, et al. (1996). "Cloning of the gene for human pemphigus vulgaris antigen (desmoglein 3), a desmosomal cadherin. Characterization of the promoter region and identification of a keratinocyte-specific cis-element". J. Biol. Chem. 271 (29): 17504–11. doi:10.1074/jbc.271.29.17504. PMID 8663392.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Marsden MD, Collins JE, Greenwood MD, et al. (1997). "Cloning and transcriptional analysis of the promoter of the human type 2 desmocollin gene (DSC2)". Gene. 186 (2): 237–47. doi:10.1016/S0378-1119(96)00715-9. PMID 9074502.
• Adams MJ, Reichel MB, King IA, et al. (1998). "Characterization of the regulatory regions in the human desmoglein genes encoding the pemphigus foliaceous and pemphigus vulgaris antigens". Biochem. J. 329. ( Pt 1): 165–74. PMC 1219028. PMID 9405290.
• Shirakata Y, Amagai M, Hanakawa Y, et al. (1998). "Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1". J. Invest. Dermatol. 110 (1): 76–8. doi:10.1046/j.1523-1747.1998.00085.x. PMID 9424092.
• Amagai M, Nishikawa T, Nousari HC, et al. (1998). "Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice". J. Clin. Invest. 102 (4): 775–82. doi:10.1172/JCI3647. PMC 508940. PMID 9710446.
• Ishikawa H, Li K, Tamai K, et al. (2001). "Cloning of the mouse desmoglein 3 gene (Dsg3): interspecies conservation within the cadherin superfamily". Exp. Dermatol. 9 (4): 229–39. doi:10.1034/j.1600-0625.2000.009004229.x. PMID 10949543.
• Czerwenka KF, Manavi M, Hosmann J, et al. (2001). "Comparative analysis of two-dimensional protein patterns in malignant and normal human breast tissue". Cancer Detect. Prev. 25 (3): 268–79. PMID 11425269.
• Weiske J, Schöneberg T, Schröder W, et al. (2001). "The fate of desmosomal proteins in apoptotic cells". J. Biol. Chem. 276 (44): 41175–81. doi:10.1074/jbc.M105769200. PMID 11500511.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Andl CD, Stanley JR (2001). "Central role of the plakoglobin-binding domain for desmoglein 3 incorporation into desmosomes". J. Invest. Dermatol. 117 (5): 1068–74. doi:10.1046/j.0022-202x.2001.01528.x. PMID 11710914.
• Merritt AJ, Berika MY, Zhai W, et al. (2002). "Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation". Mol. Cell. Biol. 22 (16): 5846–58. doi:10.1128/MCB.22.16.5846-5858.2002. PMC 133994. PMID 12138195.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hanakawa Y, Amagai M, Shirakata Y, et al. (2003). "Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation". J. Invest. Dermatol. 119 (6): 1231–6. doi:10.1046/j.1523-1747.2002.19648.x. PMID 12485422.
• Veldman C, Stauber A, Wassmuth R, et al. (2003). "Dichotomy of autoreactive Th1 and Th2 cell responses to desmoglein 3 in patients with pemphigus vulgaris (PV) and healthy carriers of PV-associated HLA class II alleles". J. Immunol. 170 (1): 635–42. doi:10.4049/jimmunol.170.1.635. PMID 12496453.
• Posthaus H, Dubois CM, Müller E (2003). "Novel insights into cadherin processing by subtilisin-like convertases". FEBS Lett. 536 (1–3): 203–8. doi:10.1016/S0014-5793(02)03897-8. PMID 12586364.