G12/G13 alpha subunits

From Wikipedia, the free encyclopedia
  (Redirected from Gα12/13)
Jump to: navigation, search
guanine nucleotide-binding protein (G protein) alpha 12
Symbol GNA12
Entrez 2768
HUGO 4380
OMIM 604394
RefSeq NM_007353
UniProt Q03113
Other data
Locus Chr. 7 p22.3
guanine nucleotide-binding protein (G protein), alpha 13
Symbol GNA13
Entrez 10672
HUGO 4381
OMIM 604406
RefSeq NM_006572
UniProt Q14344
Other data
Locus Chr. 17 q24

G12/G13 subunits are alpha units of heterotrimeric G proteins that regulate cell processes through the use of guanine nucleotide exchange factors.[1] These two subunits represent a fourth class of G protein alpha subunits.[2] They are not sensitive to pertussis toxin.[3]

G proteins G12 and G13 regulate actin cytoskeletal remodeling in cells.[4] G13 is also essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells.[5]



  1. ^ Dhanasekaran N, Dermott JM (1996). "Signaling by the G12 class of G proteins". Cell. Signal. 8 (4): 235–45. doi:10.1016/0898-6568(96)00048-4. PMID 8842523. 
  2. ^ Strathmann MP, Simon MI (1991). "G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits". Proc. Natl. Acad. Sci. U.S.A. 88 (13): 5582–6. doi:10.1073/pnas.88.13.5582. PMC 51921Freely accessible. PMID 1905812. 
  3. ^ Harhammer R, Nürnberg B, Harteneck C, Leopoldt D, Exner T, Schultz G (1996). "Distinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of G alpha 12 purified from rat brain". Biochem. J. 319. ( Pt 1): 165–71. PMC 1217750Freely accessible. PMID 8870664. 
  4. ^ Wang D, Tan YC, Kreitzer GE, Nakai Y, Shan D, Zheng Y, Huang XY (2006). "G proteins G12 and G13 control the dynamic turnover of growth factor-induced dorsal ruffles". J. Biol. Chem. 281 (43): 32660–7. doi:10.1074/jbc.M604588200. PMID 16943201. 
  5. ^ Shan D, Chen L, Wang D, Tan YC, Gu JL, Huang XY (2006). "The G protein G alpha(13) is required for growth factor-induced cell migration". Dev. Cell. 10 (6): 707–18. doi:10.1016/j.devcel.2006.03.014. PMID 16740474. 

External links[edit]