Methylphosphonyl difluoride

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Methylphosphonyl difluoride
Preferred IUPAC name
Methylphosphonic difluoride
Other names
Methylphosphonyl difluoride
Methylphosphonoyl difluoride, EA-1251
3D model (JSmol)
MeSH difluoride Methylphosphonic difluoride
Molar mass 100.00
Appearance Colorless liquid
Odor Pungent, acid-like[1]
Density 1.359 g/mL (77°F)[1]
Melting point −37 °C; −35 °F; 236 K
Boiling point 100 °C; 212 °F; 373 K
Vapor pressure 36 mmHg (77°F)[1]
Main hazards Corrosive, toxic
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Methylphosphonyl difluoride (DF), also known as EA-1251[2], is a chemical weapon precursor. Its chemical formula is CH3POF2. It is a Schedule 1 substance in the sense of the Chemical Weapons Convention. It is used for production of sarin and soman as a component of binary chemical weapons; an example is the M687 artillery shell, where it is used together with a mixture of isopropyl alcohol and isopropyl amine, producing sarin.


Methylphosphonyl difluoride can be prepared by reacting methylphosphonyl dichloride with hydrogen fluoride (HF) or sodium fluoride (NaF).


Methylphosphonyl difluoride is both reactive and corrosive. It is absorbed through skin and causes burns and mild nerve agent symptoms. It reacts with water producing HF fumes and methylphosphonic acid as a result. It is also capable of corroding glass. It has a boiling point of only 55.4 °C at normal atmospheric pressure, and thus a fairly high vapor pressure at room temperature.


  1. ^ a b c d e f Handbook of chemical and biological warfare agents (2nd ed.). CRC Press. ISBN 9780849314346.
  2. ^ "Physical properties of standard agents, candidate agents, and related compounds at several temperatures" (PDF).