Small nucleolar RNA SNORD50
| Small nucleolar RNA SNORD50 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORD50 | |
| Identifiers | |
| Symbol | SNORD50 |
| Alt. Symbols | U50 |
| Rfam | RF00278 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; CD-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000593 |
| PDB structures | PDBe |
snoRNA U50 (also known as SNORD50) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
snoRNA U50 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2]
U50 is an intronic snoRNA gene located on chromosome 6q15, at the breakpoint of chromosomal translocation t(3;6)(q27;q15). The U50HG gene is composed of six exons, whose spliced transcripts have little potential for coding a protein, and its introns produce both U50 and U50-like (U50') snoRNAs that are localised in nucleoli.[3] There is evidence that the U50 paralogues form a novel family of genes controlling oncogenesis and sensitivity to therapy in cancer.[4][5]
References
- ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1128/MCB.22.19.6663-6668.2002, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with
|doi=10.1128/MCB.22.19.6663-6668.2002instead. - ^ Kiss-Laszlo, Z; Henry Y; Bachellerie JP; Caizergues-Ferrer M; Kiss T (1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell. 85 (7): 1077–1088. doi:10.1016/S0092-8674(00)81308-2. PMID 8674114.
- ^ Tanaka, R; Satoh H; Moriyama M; Satoh K; Morishita Y; Yoshida S; Watanabe T; Nakamura Y; Mori S (2000). "Intronic U50 small-nucleolar-RNA (snoRNA) host gene of no protein-coding potential is mapped at the chromosome breakpoint t(3;6)(q27;q15) of human B-cell lymphoma". Genes Cells. 5 (4): 277–287. doi:10.1046/j.1365-2443.2000.00325.x. PMID 10792466.
- ^ Mourtada-Maarabouni M, Pickard MR, Hedge VL, Farzaneh F, Williams GT (October 2008). "GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer". Oncogene. 28 (2): 195–208. doi:10.1038/onc.2008.373. PMID 18836484.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Dong XY, Guo P, Boyd J; et al. (August 2009). "Implication of snoRNA U50 in human breast cancer". J Genet Genomics. 36 (8): 447–54. doi:10.1016/S1673-8527(08)60134-4. PMC 2854654. PMID 19683667.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link)
External links
- Page for Small nucleolar RNA SNORD50 at Rfam
- Entry for SNORD50 at snoRNABase
- Entry for SNORD50B at snoRNABase
 | This molecular or cell biology article is a stub. You can help Wikipedia by expanding it. |