Fluproquazone

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Fluproquazone
Fluproquazone.svg
Systematic (IUPAC) name
4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one
Clinical data
Legal status ?
Identifiers
CAS number 40507-23-1
ATC code None
PubChem CID 38503
ChemSpider 35289 YesY
UNII U4K85O58HD YesY
KEGG D04229 YesY
Chemical data
Formula C18H17FN2O 
Mol. mass 296.339 g/mol
 YesY (what is this?)  (verify)

Fluproquazone (trade name Tormosyl) is a quinazolinone derivative with potent analgesic[1][2] and antipyretic[3] effects and also anti-inflammatory action. It has been shown to be effective in a variety of animal species after both oral and parenteral administration, and has a duration of action of several hours. The compound is many times more potent than acetylsalicylic acid and clinically generally resembles ibuprofen and indoprofen in its pharmacological effects, but with significantly less ulcerogenic activity.[4] It is mainly used in the treatment of arthritis[5] and post-operative pain.[6]

Chemistry[edit]

Fluproquazone syn.png

Lindler, J.; Mattner, P. G.; Salmond, W. G.; 1973, U.S. Patent 3,759,920.

References[edit]

  1. ^ Mohing W, Suckert R, Lataste X. Comparative study of fluproquazone in the management of post-operative pain. Arzneimittelforschung. 1981;31(5a):918-20.
  2. ^ Wheatley D. Analgesic properties of fluproquazone. Rheumatology and Rehabilitation. 1982 May;21(2):98-100.
  3. ^ Fankhauser S, Laube W, Marti HR, Schultheiss HR, Vogtlin J, von Graffenried B. Antipyretic activity of fluproquazone in man. Arzneimittelforschung. 1981;31(5a):934-5.
  4. ^ Gillberg R, Korsan-Bengtsen K, Magnusson B, Nyberg G. Gastrointestinal blood loss, gastroscopy and coagulation factors in normal volunteers during administration of acetylsalicylic acid and fluproquazone. Scandinavian Journal of Rheumatology. 1981;10(4):342-6.
  5. ^ Huskisson EC, Bryans R, Scott J. Fluproquazone for osteoarthritis. Rheumatology and Rehabilitation. 1981 May;20(2):122-4.
  6. ^ Haanaes HR, Benterud UJ, Skoglund LA. RF 46-790 versus paracetamol: effect on post-operative pain. International Journal of Clinical Pharmacology, Therapy, and Toxicology. 1986 Nov;24(11):598-601.