Suprofen

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Suprofen.svg
Systematic (IUPAC) name
(RS)-2-[4-(2-thienylcarbonyl)phenyl]propanoic acid
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat.
Legal status
  • Discontinued
Routes Oral, eye drops
Pharmacokinetic data
Protein binding 20%
Identifiers
CAS number 40828-46-4 YesY
ATC code M01AE07
PubChem CID 5359
DrugBank DB00870
ChemSpider 5166 N
UNII 988GU2F9PE YesY
KEGG D00452 YesY
ChEBI CHEBI:9362 N
ChEMBL CHEMBL956 N
Chemical data
Formula C14H12O3S 
Mol. mass 260.309 g/mol
 N (what is this?)  (verify)

Suprofen is a non-steroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica[1] that was marketed as 1% eye drops under the trade name Profenal.

Uses[edit]

Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects.[2] It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.[3] This application has been discontinued as well, at least in the US.[4]

References[edit]

  1. ^ Janssen, Paul A.; Van Daele, Georges H. P.; Boey, Jozef M. "Antiphlogistic aroyl-substituted phenylacetic acid derivatives" (1974) DE 2353357 
  2. ^ Nies A S (1988). "Renal effects of nonsteroidal anti-inflammatory drugs". Agents and actions 24: 95–106. doi:10.1007/978-3-0348-9160-8_9. 
  3. ^ Guidance for FDA Staff and Industry Compliance Policy Guides Manual, Sec. 460.200
  4. ^ Drugs.com: suprofen ophthalmic