Flurbiprofen

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Flurbiprofen
Flurbiprofen.svg
Systematic (IUPAC) name
(RS)-2-(2-fluorobiphenyl-4-yl)propanoic acid
Clinical data
Trade names Ansaid, Ocufen, Strepfen
AHFS/Drugs.com monograph
MedlinePlus a687005
Pregnancy cat. C (U.S.), B2 (Au)
Legal status POM
Routes Oral
Pharmacokinetic data
Protein binding > 99%
Metabolism Hepatic (CYP2C9)
Half-life 4.7-5.7 hours
Excretion Renal
Identifiers
CAS number 5104-49-4 YesY
ATC code M01AE09 , M02AA19, R02AX01, S01BC04
PubChem CID 3394
IUPHAR ligand 4194
DrugBank DB00712
ChemSpider 3277 YesY
UNII 5GRO578KLP YesY
KEGG D00330 YesY
ChEBI CHEBI:5130 YesY
ChEMBL CHEMBL563 YesY
Synonyms (±)-2-fluoro-α-methyl-(1,1'-biphenyl)-4-acetic acid
PDB ligand ID FLP (PDBe, RCSB PDB)
Chemical data
Formula C15H13FO2 
Mol. mass 244.261 g/mol
Physical data
Melt. point 117 °C (243 °F)
 YesY (what is this?)  (verify)

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs) used to treat the inflammation and pain of arthritis.[1] It is known as "Ansaid" marketed by Pfizer and "Froben" by Abbott.

Flurbiprofen is also used as an active ingredient in some kinds of throat lozenges (Strepsils Intensive).

A single enantiomer of flurbiprofen, tarenflurbil [(R)-flurbiprofen)], is currently in clinical trials for the treatment of metastatic prostate cancer.

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