Indoprofen

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Indoprofen
Indoprofen.svg
Systematic (IUPAC) name
2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)
phenyl]propanoic acid
Clinical data
Legal status
  • Withdrawn
Routes Oral
Pharmacokinetic data
Bioavailability High (rapid and complete absorption)
Metabolism Glucuronidation
Half-life 2.3 hours
Excretion Renal
Identifiers
CAS number 31842-01-0 YesY
ATC code M01AE10
PubChem CID 3718
DrugBank DB08951
ChemSpider 3587 YesY
UNII CPE46ZU14N YesY
KEGG D04530 YesY
ChEBI CHEBI:76162 N
ChEMBL CHEMBL15870 YesY
Chemical data
Formula C17H15NO3 
Molecular mass 281.306 g/mol
 N (what is this?)  (verify)

Indoprofen is a non-steroidal anti-inflammatory drug. It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.[1]

A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies.[1][2]

References[edit]

  1. ^ a b Frazin, Natalie (March 9, 2005). "Pain Reliever May Provide Clues for Treating Spinal Muscular Atrophy". United States National Institute of Neurological Disorders and Stroke. Retrieved 2007-10-06. 
  2. ^ Lunn MR; Root DE; Martino AM et al. (2004). "Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism". Chem Biol 11 (11): 1489–1493. doi:10.1016/j.chembiol.2004.08.024. PMC 3160629. PMID 15555999.