Antrafenine

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Antrafenine
Antrafenine.svg
Systematic (IUPAC) name
2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl 2-{[7-(trifluoromethyl)quinolin-4-yl]amino}benzoate
Clinical data
Legal status Prescription only
Routes Oral
Pharmacokinetic data
Metabolism Hepatic
Excretion Renal
Identifiers
CAS number 55300-30-6
ATC code None
PubChem CID 68723
DrugBank DB01419
ChemSpider 61973 YesY
UNII 21FS93Y6OE YesY
ChEMBL CHEMBL345524 YesY
Chemical data
Formula C30H26F6N4O2 
Mol. mass 588.543 g/mol
 YesY (what is this?)  (verify)

Antrafenine (Stakane) is a phenylpiperazine derivative drug invented in 1979.[1] It acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen,[2] but is not widely used as it has largely been replaced by newer drugs.

See also[edit]

References[edit]

  1. ^ Manoury PM, Dumas AP, Najer H, Branceni D, Prouteau M, Lefevre-Borg FM. Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates. Journal of Medicinal Chemistry. 1979 May;22(5):554-9.
  2. ^ Leatham PA, Bird HA, Wright V, Seymour D, Gordon A. A double blind study of antrafenine, naproxen and placebo in osteoarthrosis. European Journal of Rheumatology and Inflammation. 1983;6(2):209-11.