Prostaglandin F receptor

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Prostaglandin F receptor (FP)
Symbols PTGFR ; FP
External IDs OMIM600563 MGI97796 HomoloGene741 IUPHAR: 344 ChEMBL: 1987 GeneCards: PTGFR Gene
RNA expression pattern
PBB GE PTGFR 207177 at tn.png
More reference expression data
Species Human Mouse
Entrez 5737 19220
Ensembl ENSG00000122420 ENSMUSG00000028036
UniProt P43088 P43117
RefSeq (mRNA) NM_000959 NM_008966
RefSeq (protein) NP_000950 NP_032992
Location (UCSC) Chr 1:
78.77 – 79.01 Mb
Chr 3:
151.8 – 151.84 Mb
PubMed search [1] [2]

Prostaglandin F receptor (FP) is a receptor for Prostaglandin F. It is encoded by the gene PTGFR.[1]

It is a member of the G-protein coupled receptor family. Activation of FP Receptor results in activation of G-protein subunit Gq, increasing IP3 and DAG.

Two transcript variants encoding different isoforms have been found for this gene.[1]


Main effects of prostaglandin binding to the receptor are:

Via activation of this receptor, PGF2-alpha mediates luteolysis,[1] and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus and gastrointestinal tract sphincters.[3]

Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition.[4]

See also[edit]


  1. ^ a b c "Entrez Gene: PTGFR prostaglandin F receptor (FP)". 
  2. ^ Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5th ed., Churchill Livingstone 2003) Page 234
  3. ^ Signal transduction in lower esophageal sphincter circular muscle Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D.
  4. ^ Sugimoto Y; Yamasaki A; Segi E et al. (1997). "Failure of parturition in mice lacking the prostaglandin F receptor". Science 277 (5326): 681–3. doi:10.1126/science.277.5326.681. PMID 9235889. 

External links[edit]

  • "Prostanoid Receptors: FP". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

  • Duncan AM; Anderson LL; Funk CD et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family". Genomics 25 (3): 740–2. doi:10.1016/0888-7543(95)80022-E. PMID 7759114. 
  • Lake S; Gullberg H; Wahlqvist J et al. (1995). "Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor". FEBS Lett. 355 (3): 317–25. doi:10.1016/0014-5793(94)01198-2. PMID 7988697. 
  • Bastien L; Sawyer N; Grygorczyk R et al. (1994). "Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype". J. Biol. Chem. 269 (16): 11873–7. PMID 8163486. 
  • Funk CD; Furci L; FitzGerald GA et al. (1994). "Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype". J. Biol. Chem. 268 (35): 26767–72. PMID 8253813. 
  • Abramovitz M; Boie Y; Nguyen T et al. (1994). "Cloning and expression of a cDNA for the human prostanoid FP receptor". J. Biol. Chem. 269 (4): 2632–6. PMID 8300593. 
  • Sugimoto Y; Yamasaki A; Segi E et al. (1997). "Failure of parturition in mice lacking the prostaglandin F receptor". Science 277 (5326): 681–3. doi:10.1126/science.277.5326.681. PMID 9235889. 
  • Kunapuli P, Lawson JA, Rokach J, FitzGerald GA (1997). "Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha". J. Biol. Chem. 272 (43): 27147–54. doi:10.1074/jbc.272.43.27147. PMID 9341156. 
  • Betz R; Lagercrantz J; Kedra D et al. (1999). "Genomic structure, 5' flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene". Biochem. Biophys. Res. Commun. 254 (2): 413–6. doi:10.1006/bbrc.1998.9827. PMID 9918852. 
  • Kyveris A, Maruscak E, Senchyna M (2002). "Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR". Mol. Vis. 8: 51–8. PMID 11951086. 
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Neuschäfer-Rube F; Engemaier E; Koch S et al. (2003). "Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor". Biochem. J. 371 (Pt 2): 443–9. doi:10.1042/BJ20021429. PMC 1223288. PMID 12519077. 
  • Zaragoza DB, Wilson R, Eyster K, Olson DM (2004). "Cloning and characterization of the promoter region of the human prostaglandin F2alpha receptor gene". Biochim. Biophys. Acta 1676 (2): 193–202. doi:10.1016/j.bbaexp.2003.11.004. PMID 14746914. 
  • Sales KJ; Milne SA; Williams AR et al. (2004). "Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways". J. Clin. Endocrinol. Metab. 89 (2): 986–93. doi:10.1210/jc.2003-031434. PMID 14764825. 
  • Vielhauer GA, Fujino H, Regan JW (2004). "Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor". Arch. Biochem. Biophys. 421 (2): 175–85. doi:10.1016/ PMID 14984197. 
  • Jin P; Fu GK; Wilson AD et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes". Genomics 83 (4): 566–71. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279. 
  • Sugino N; Karube-Harada A; Taketani T et al. (2004). "Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation". J. Reprod. Dev. 50 (2): 215–25. doi:10.1262/jrd.50.215. PMID 15118249. 
  • Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Scott G; Jacobs S; Leopardi S et al. (2005). "Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiation". Exp. Cell Res. 304 (2): 407–16. doi:10.1016/j.yexcr.2004.11.016. PMID 15748887. 
  • Mandal AK; Ray R; Zhang Z et al. (2005). "Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators". J. Biol. Chem. 280 (38): 32897–904. doi:10.1074/jbc.M502375200. PMID 16061484. 
  • Hébert RL, Carmosino M, Saito O et al. (2005). "Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct.". J. Biol. Chem. 280 (41): 35028–37. doi:10.1074/jbc.M505852200. PMID 16096282. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.