Prostaglandin F receptor

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Prostaglandin F receptor (FP)
Identifiers
Symbols PTGFR ; FP
External IDs OMIM600563 MGI97796 HomoloGene741 IUPHAR: FP ChEMBL: 1987 GeneCards: PTGFR Gene
RNA expression pattern
PBB GE PTGFR 207177 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5737 19220
Ensembl ENSG00000122420 ENSMUSG00000028036
UniProt P43088 P43117
RefSeq (mRNA) NM_000959 NM_008966
RefSeq (protein) NP_000950 NP_032992
Location (UCSC) Chr 1:
78.77 – 79.01 Mb
Chr 3:
151.8 – 151.84 Mb
PubMed search [1] [2]

Prostaglandin F receptor (FP) is a receptor for Prostaglandin F. It is encoded by the gene PTGFR.[1]

It is a member of the G-protein coupled receptor family. Activation of FP Receptor results in activation of G-protein subunit Gq, increasing IP3 and DAG.

Two transcript variants encoding different isoforms have been found for this gene.[1]

Functions[edit]

Main effects of prostaglandin binding to the receptor are:

Via activation of this receptor, PGF2-alpha mediates luteolysis,[1] and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus and gastrointestinal tract sphincters.[3]

Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition.[4]

See also[edit]

References[edit]

  1. ^ a b c "Entrez Gene: PTGFR prostaglandin F receptor (FP)". 
  2. ^ Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5:th ed., Churchill Livingstone 2003) Page 234
  3. ^ Signal transduction in lower esophageal sphincter circular muscle Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D.
  4. ^ Sugimoto Y, Yamasaki A, Segi E et al. (1997). "Failure of parturition in mice lacking the prostaglandin F receptor". Science 277 (5326): 681–3. doi:10.1126/science.277.5326.681. PMID 9235889. 

External links[edit]

  • "Prostanoid Receptors: FP". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.