Prostaglandin F receptor

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Prostaglandin F receptor (FP)
Symbols PTGFR ; FP
External IDs OMIM600563 MGI97796 HomoloGene741 IUPHAR: FP ChEMBL: 1987 GeneCards: PTGFR Gene
RNA expression pattern
PBB GE PTGFR 207177 at tn.png
More reference expression data
Species Human Mouse
Entrez 5737 19220
Ensembl ENSG00000122420 ENSMUSG00000028036
UniProt P43088 P43117
RefSeq (mRNA) NM_000959 NM_008966
RefSeq (protein) NP_000950 NP_032992
Location (UCSC) Chr 1:
78.77 – 79.01 Mb
Chr 3:
151.8 – 151.84 Mb
PubMed search [1] [2]

Prostaglandin F receptor (FP) is a receptor for Prostaglandin F. It is encoded by the gene PTGFR.[1]

It is a member of the G-protein coupled receptor family. Activation of FP Receptor results in activation of G-protein subunit Gq, increasing IP3 and DAG.

Two transcript variants encoding different isoforms have been found for this gene.[1]


Main effects of prostaglandin binding to the receptor are:

Via activation of this receptor, PGF2-alpha mediates luteolysis,[1] and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus and gastrointestinal tract sphincters.[3]

Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition.[4]

See also[edit]


  1. ^ a b c "Entrez Gene: PTGFR prostaglandin F receptor (FP)". 
  2. ^ Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5:th ed., Churchill Livingstone 2003) Page 234
  3. ^ Signal transduction in lower esophageal sphincter circular muscle Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D.
  4. ^ Sugimoto Y, Yamasaki A, Segi E et al. (1997). "Failure of parturition in mice lacking the prostaglandin F receptor". Science 277 (5326): 681–3. doi:10.1126/science.277.5326.681. PMID 9235889. 

External links[edit]

  • "Prostanoid Receptors: FP". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.