Morphiceptin

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Morphiceptin
Morphiceptin.svg
Identifiers
CAS number 87777-29-5 YesY
PubChem 119303
ChemSpider 3754959 N
Jmol-3D images Image 1
Properties
Molecular formula C28H35N5O5
Molar mass 521.6 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Morphiceptin is a tetrapeptide (Tyr-Pro-Phe-Pro-NH2) that is a selective μ-opioid receptor agonist. It is derived from β-casomorphin and has over 1,000 times selectivity for μ- over δ-opioid receptors. When injected intracerebroventricularly (into the ventricular system of the brain), morphiceptin had an analgesic ED50 of 1.7 nmol per animal. The analgesic effects of morphiceptin were reversed by naloxone, meaning that the analgesic effect is mediated by the μ-opioid receptor.[2]

See also[edit]

References[edit]

  1. ^ "Morphiceptin". Morphiceptin. ChemBase. Retrieved 1 August 2011. 
  2. ^ Chang, K. "Analgesic activity of intracerebroventricular administration of morphiceptin and β-casomorphins: Correlation with the morphine (μ) receptor binding affinity". Life Sciences 1982 (18): 1547–1551. doi:10.1016/0024-3205(82)90242-9.