Naltriben

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Naltriben
Naltriben.svg
Clinical data
Legal status
?
Identifiers
CAS number 111555-58-9
ATC code None
PubChem CID 5486827
IUPHAR ligand 1640
ChemSpider 4589081 YesY
ChEMBL CHEMBL100940 YesY
Chemical data
Formula C26H25NO4 
Mol. mass 415.480 g/mol
 YesY (what is this?)  (verify)

Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ1 and δ2 subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors.[1] It also acts as a κ-opioid agonist at high doses.[2]

References[edit]

  1. ^ Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. Journal of Pharmacology and Experimental Therapeutics. 1991 May;257(2):676-80. PMID 1851833
  2. ^ Stewart PE, Holper EM, Hammond DL. Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes. Life Sciences. 1994;55(4):PL79-84. PMID 8028443