Viminol

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Viminol
Viminol2DACS.svg
Systematic (IUPAC) name
1-[1-(2-Chlorobenzyl)-1H-pyrrol-2-yl]-2-(di-sec-butylamino)ethanol
Clinical data
AHFS/Drugs.com International Drug Names
Legal status OTC
Routes Oral
Identifiers
CAS number 21363-18-8 YesY
ATC code N02BG05
PubChem CID 65697
ChemSpider 59125 N
UNII TPV54G6XBG YesY
KEGG D07295 YesY
ChEMBL CHEMBL2104940 N
Synonyms Viminol, Dividol
Chemical data
Formula C21H31ClN2O 
Mol. mass 362.94 g/mol
 N (what is this?)  (verify)

Viminol (marketed under the brandname Dividol) is an opioid analgesic developed by the drugs company Zambon in the 1960s.[1] It has an unusual chemical structure that is not similar to other opioids.[2][3]

Viminol has both antitussive (cough suppressing) and analgesic (pain reducing) effects. It has six different stereoisomers which have varying properties. 4 are inactive, the 2-(R)N,N-(S) isomer being a μ-opioid full agonist around 5.5 times more potent than morphine while the 2-(S)-N,N-(R) isomer is an antagonist.[4][5] Since vimonol is supplied as a racemic mixture of isomers, the overall effect produces a mixed agonist–antagonist profile similar to that of opioids such as pentazocine, although with somewhat fewer side effects.[6]

Viminol has similar effects to other opioids, and produces analgesia, sedation and euphoria.

Side Effects[edit]

Side effects are similar to other opioids, and can include:

However, since viminol is supplied as a racemic mixture of agonist and antagonist isomers, the abuse potential and respiratory depression tends to be less than that of μ-opioid full agonist drugs.

References[edit]

  1. ^ US patent 3539589, Uberto M Teotino and Davide Della Bella, "1-(α-PYRRYL)-2-AMINO ETHANOLS", published 1967-05-08, issued 1970-10-11 
  2. ^ Contri AM. Chromatographic separation of diastereoisomers of aminoalcohol salts and their densitometric determination. (Italian). Il Farmaco. 1981 Apr;36(4):215-22.
  3. ^ Neto JM, Murad JE, Monteiro SS. Psychopharmacological properties of the viminol-p-hydroxybenzoate. Revista Brasileira de Pesquisas Medicas e Biologicas. 1977 Dec;10(6):361-8.
  4. ^ US Patent 3857857 - Davide Della Bella, Carlo Veneziani Bresso, Dario Chiarnio Monza & Uberio Maria Tiotino 'Stereoisomers of 1(1'(-O-Chlorobenzyl)-2'-Pyrryl)-2-Disec.Butylamino-Ethanol'
  5. ^ Shook JE, Kallman MJ, Dewey WL. The discriminative stimulus properties of the R2 isomer of viminol. Pharmacology, Biochemistry and Behaviour. 1984 Jan;20(1):59-62.
  6. ^ Cinelli M, Costa V, Ventresca GP, Lodola E. Viminol R2 analgesic activity in patients with postoperative pain: comparison with pentazocine. International Journal of Clinical Pharmacology, Therapy and Toxicology. 1986 May;24(5):232-5.