Moxazocine

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Moxazocine
Moxazocine structure.svg
Systematic (IUPAC) name
(1S,9R,13S)-10-(cyclopropylmethyl)-13-methoxy-1-methyl-10-azatricyclo[7.3.1.02,7]trideca-2,4,6-trien-4-ol
Clinical data
Legal status ?
Identifiers
CAS number 58239-89-7
ATC code ?
ChemSpider 16737008
Chemical data
Formula C18H25NO2 
Mol. mass 287.397 g/mol

Moxazocine (BL-4566) is an opioid analgesic of the benzomorphan family which was never marketed.[1] It acts as a partial agonist or mixed agonist/antagonist of the opioid receptors and binds preferentially to the κ-opioid receptor.[2] Despite its failure to reach the market, clinical studies demonstrated moxazocine to be approximately 10x as potent by weight as morphine as an analgesic.[3]

See also[edit]

References[edit]

  1. ^ Dictionary of Pharmacological Agents Volume 2. CRC Press. p. 1382. ISBN 978-0-412-46630-4. Retrieved 22 April 2012. 
  2. ^ Hayes AG, Sheehan MJ, Tyers MB (August 1987). "Differential sensitivity of models of antinociception in the rat, mouse and guinea-pig to mu- and kappa-opioid receptor agonists". British Journal of Pharmacology 91 (4): 823–32. PMC 1853585. PMID 2822190. 
  3. ^ Dobkin, Allen B; Esposito, Barbara F; Noveck, Robert J; Caruso, Frank S (October 1977). "Moxazocine and morphine in patients with severe postoperative pain". Current Therapeutic Research. 22(4): 469–478.