Matrine

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Matrine
Matrine structure.png
Systematic (IUPAC) name
(7aS,13aR,13bR,13cS)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one
Clinical data
Legal status Unscheduled
Identifiers
CAS number 519-02-8 YesY
ATC code None
PubChem CID 91466
ChemSpider 553788 YesY
ChEMBL CHEMBL204860 N
Chemical data
Formula C15H24N2O 
Mol. mass 248.364 g/mol
 N (what is this?)  (verify)

Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects,[1] and action as a kappa opioid receptor and µ-receptor agonist.[2][3]

Matrine possesses strong antitumor activities in vitro and in vivo. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities.[4] Matrine is a component of the traditional Chinese medical herb Sophora flavescens Ait.

Matrine and the related compound oxymatrine have an antifeedant effect against Formosan subterranean termite.[5]

References[edit]

  1. ^ Zhang, Y.; Zhang, H.; Yu, P.; Liu, Q.; Liu, K.; Duan, H.; Luan, G.; Yagasaki, K.; Zhang, G. (April 2009). "Effects of Matrine against the Growth of Human Lung Cancer and Hepatoma Cells as well as Lung Cancer Cell Migration". Cytotechnology 59 (3): 191–200. doi:10.1007/s10616-009-9211-2. PMC 2774570. PMID 19649719. 
  2. ^ Xiao, P.; Kubo, H.; Ohsawa, M.; Higashiyama, K.; Nagase, H.; Yan, Y. N.; Li, J. S.; Kamei, J.; Ohmiya, S. (April 1999). "Kappa-Opioid Receptor-Mediated Antinociceptive Effects of Stereoisomers and Derivatives of (+)-Matrine in Mice". Planta Medica 65 (3): 230–233. doi:10.1055/s-1999-14080. PMID 10232067. 
  3. ^ Higashiyama, K.; Takeuchi, Y.; Yamauchi, T.; Imai, S.; Kamei, J.; Yajima, Y.; Narita, M.; Suzuki, T. (May 2005). "Implication of the Descending Dynorphinergic Neuron Projecting to the Spinal Cord in the (+)-Matrine- and (+)-Allomatrine-Induced Antinociceptive Effects" (pdf). Biological and Pharmaceutical Bulletin 28 (5): 845–848. doi:10.1248/bpb.28.845. PMID 15863891. 
  4. ^ Ma, L.; Wen, S.; Zhan, Y.; He, Y.; Liu, X.; Jiang, J. (2008). "Anticancer Effects of the Chinese Medicine Matrine on Murine Hepatocellular Carcinoma Cells". Planta Medica 74 (3): 245–251. doi:10.1055/s-2008-1034304. PMID 18283616. 
  5. ^ Mao, L.; Henderson, G. (2007). "Antifeedant Activity and Acute and Residual Toxicity of Alkaloids from Sophora flavescens (Leguminosae) against Formosan Subterranean Termites (Isoptera: Rhinotermitidae)". Journal of Economic Entomology 100 (3): 866–870. doi:10.1603/0022-0493(2007)100[866:AAAAAR]2.0.CO;2. PMID 17598549.