|Jmol-3D images||Image 1|
|Molar mass||892.01 g mol−1|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C or 77 °F, 100 kPa)|
Valorphin, also known as VV-hemorphin-5, is a naturally occurring, endogenous opioid heptapeptide of the hemorphin family with the amino acid sequence H-Val-Val-Tyr-Pro-Trp-Thr-Gln-OH. It is produced in the body via proteolyic cleavage of residues 33-39 of the β-chain of hemoglobin. Valorphin binds preferentially to the μ-opioid receptor and produces effects such as analgesia and self-administration in animals. It also possesses cytotoxic and antiproliferative properties against tumor cells, the mediation of which, on account of the fact that they are reversed by naloxone, appears to be dependent on the opioid receptors.
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- Blishchenko EY, Sazonova OV, Kalinina OA, et al. (January 2005). "Antitumor effect of valorphin in vitro and in vivo: combined action with cytostatic drugs". Cancer Biology & Therapy 4 (1): 118–24. PMID 15662114.