Leprosy
- For the Hebrew Bible term and its varied meanings, see Tzaraath. For other uses, see Leprosy (disambiguation).
Leprosy | |
---|---|
Specialty | Infectious diseases ![]() |
Frequency | 0.002413966% (world) |
Leprosy or Hansen's disease (HD), named after physician Gerhard Armauer Hansen, is a chronic disease caused by the bacteria Mycobacterium leprae and Mycobacterium lepromatosis.[1][2] Leprosy is primarily a granulomatous disease of the peripheral nerves and mucosa of the upper respiratory tract; skin lesions are the primary external sign.[3] Left untreated, leprosy can be progressive, causing permanent damage to the skin, nerves, limbs and eyes. Contrary to folklore, leprosy does not cause body parts to fall off, although they can become numb and/or diseased as a result of the disease.[4][5]
Leprosy has affected humanity for over 4,000 years,[6] and was well-recognized in the civilizations of ancient China, Egypt, and India.[7] DNA taken from the shrouded remains of a man discovered in a tomb next to the Old City of Jerusalem shows him to be the earliest human proven to have suffered from leprosy.[8] In 1995, the World Health Organization (WHO) estimated that between 2 and 3 million people were permanently disabled because of leprosy at that time.[9] In the past 20 years, 15 million people worldwide have been cured of leprosy.[10] Although the forced quarantine or segregation of patients is unnecessary in places where adequate treatments are available, many leper colonies still remain around the world in countries such as India (where there are still more than 1,000 leper colonies),[10] China,[11] Romania,[12] Egypt, Nepal, Somalia, Liberia, Vietnam,[13] and Japan.[14] Leprosy was once believed to be highly contagious and sexually transmitted, and was treated with mercury—all of which applied to syphilis which was first described in 1530. It is now thought that many early cases of leprosy could have been syphilis.[15] Leprosy is now known to be neither sexually transmitted nor highly infectious after treatment, as approximately 95% of people are naturally immune[16] and sufferers are no longer infectious after as little as 2 weeks of treatment.
The age-old social stigma, in other words, leprosy stigma[17] associated with the advanced form of leprosy lingers in many areas, and remains a major obstacle to self-reporting and early treatment. Effective treatment for leprosy appeared in the late 1930s with the introduction of dapsone and its derivatives. Leprosy bacilli resistant to dapsone soon evolved and, due to overuse of dapsone, became widespread. It was not until the introduction of multidrug therapy (MDT) in the early 1980s that the disease could be diagnosed and treated successfully within the community.[18]
MDT for multibacillary leprosy consists of rifampicin, dapsone, and clofazimine taken over 12 months. Dosages adjusted appropriately for children and adults are available in all Primary Health Centres in the form of blister packages.[18] Single dose MDT for single lesion leprosy consists of rifampicin, ofloxacin, and minocycline. The move towards single dose treatment strategies has reduced the prevalence of disease in some regions since prevalence is dependent on duration of treatment.
World Leprosy Day was created to draw awareness to leprosy and its sufferers.
Classification
There are several different approaches for classifying leprosy, but parallels exist.
- The World Health Organization system distinguishes "paucibacillary" and "multibacillary" based upon the proliferation of bacteria[19] ("pauci-" refers to a low quantity.)
- The SHAY scale provides five gradations.[20][21]
- The ICD-10, though developed by the WHO, uses Ridley-Jopling and not the WHO system. It also adds an indeterminate ("I") entry.[citation needed]
- In MeSH, three groupings are used.
WHO | Ridley-Jopling | ICD-10 | MeSH | Description | Lepromin test | Immune target |
---|---|---|---|---|---|---|
Paucibacillary | tuberculoid ("TT"), borderline tuberculoid ("BT") | A30.1, A30.2 | Tuberculoid | It is characterized by one or more hypopigmented skin macules and anaesthetic patches, where skin sensations are lost because of damaged peripheral nerves that have been attacked by the human host's immune cells. | Positive | bacillus (Th1) |
Multibacillary | midborderline or borderline ("BB") | A30.3 | Borderline | Borderline leprosy is of intermediate severity and is the most common form. Skin lesions resemble tuberculoid leprosy but are more numerous and irregular; large patches may affect a whole limb, and peripheral nerve involvement with weakness and loss of sensation is common. This type is unstable and may become more like lepromatous leprosy or may undergo a reversal reaction, becoming more like the tuberculoid form. | ||
Multibacillary | borderline lepromatous ("BL"), and lepromatous ("LL") | A30.4, A30.5 | Lepromatous | It is associated with symmetric skin lesions, nodules, plaques, thickened dermis, and frequent involvement of the nasal mucosa resulting in nasal congestion and epistaxis (nose bleeds) but typically detectable nerve damage is late. | Negative | plasmid inside bacillus (Th2) |
There is a difference in immune response to the tuberculoid and lepromatous forms.[22]
Hansen's disease may also be divided into the following types:[23]: 344–346
This disease may also occur with only neural involvement, without skin lesions.[7][24][25][26][27][28] This disease is also known as Hansen's Disease.
Signs and symptoms
Skin lesions are the primary external sign.[3] Left untreated, leprosy can be progressive, causing permanent damage to the skin, nerves, limbs and eyes. Contrary to folklore, leprosy does not cause body parts to fall off, although they can become numb and/or diseased as a result of the disease.[4][29]
Cause
Mycobacterium leprae
![](http://upload.wikimedia.org/wikipedia/commons/thumb/7/7e/M_leprae_ziehl_nielsen2.jpg/220px-M_leprae_ziehl_nielsen2.jpg)
Mycobacterium leprae and Mycobacterium lepromatosis are the causative agents of leprosy. M. lepromatosis is a relatively newly identified mycobacterium which was isolated from a fatal case of diffuse lepromatous leprosy in 2008.[2][3]
An intracellular, acid-fast bacterium, M. leprae is aerobic and rod-shaped, and is surrounded by the waxy cell membrane coating characteristic of Mycobacterium species.[30]
Due to extensive loss of genes necessary for independent growth, M. leprae and M. lepromatosis are unculturable in the laboratory, a factor which leads to difficulty in definitively identifying the organism under a strict interpretation of Koch's postulates.[2][31] The use of non-culture-based techniques such as molecular genetics has allowed for alternative establishment of causation.
While the causative organisms have to date been impossible to culture in vitro it has been possible to grow them in animals. Charles Shepard, chairman of the United States Leprosy Panel, successfully grew the organisms in the footpads of mice in 1960. This method was improved with the use of congenitally athymic mice ('nude mice') in 1970 by Joseph Colson and Richard Hilson at St George's Hospital, London.
A second animal model was developed by Eleanor Storrs at the Gulf South Research Institute. Dr Storrs had worked on the nine-banded armadillo for her PhD, because this animal had a lower body temperature than humans and might therefore be a suitable animal model. The work started in 1968 with material provided by Waldemar Kirchheimer at the United States Public Health Leprosarium in Carville, Louisiana. These experiments proved unsuccessful but additional work in 1970 with material provided by Chapman Binford, medical director of the Leonard's Wood Memorial, was successful. The papers describing this model led to a dispute of priority. Further controversy was generated when it was discovered that wild armadillos in Louisiana were naturally infected with leprosy.
Naturally occurring infection also has been reported in non-human primates including the African chimpanzee, sooty mangabey, and cynomolgus macaque.
Genetics
Several genes have been associated with a susceptibility to leprosy.
Name | Locus | OMIM | Gene |
---|---|---|---|
LPRS1 | 10p13 | Template:OMIM2 | |
LPRS2 | 6q25 | Template:OMIM2 | PARK2, PACRG |
LPRS3 | 4q32 | Template:OMIM2 | TLR2 |
LPRS4 | 6p21.3 | Template:OMIM2 | LTA |
Pathophysiology
![](http://upload.wikimedia.org/wikipedia/commons/thumb/6/61/Bundesarchiv_Bild_105-DOA0199%2C_Deutsch-Ostafrika%2C_Leprakranke.jpg/300px-Bundesarchiv_Bild_105-DOA0199%2C_Deutsch-Ostafrika%2C_Leprakranke.jpg)
The mechanism of transmission of leprosy is prolonged close contact and transmission by nasal droplet.[7] The only creature other than humans that is known to contract leprosy is the nine-banded armadillo.[32] The bacterium can also be grown in the laboratory by injection into the footpads of mice.[33] There is evidence that not all people who are infected with M. leprae develop leprosy, and genetic factors have long been thought to play a role, due to the observation of clustering of leprosy around certain families, and the failure to understand why certain individuals develop lepromatous leprosy while others develop other types of leprosy.[34] It is estimated that due to genetic factors, only 5% of the population is susceptible to leprosy.[35] This is mostly because the body is naturally immune to the bacteria, and those persons who do become infected are experiencing a severe allergic reaction to the disease. However, the role of genetic factors is not entirely clear in determining this clinical expression. In addition, malnutrition and prolonged exposure to infected persons may play a role in development of the overt disease.
The most widely held belief is that the disease is transmitted by contact between infected persons and healthy persons.[36] In general, closeness of contact is related to the dose of infection, which in turn is related to the occurrence of disease. Of the various situations that promote close contact, contact within the household is the only one that is easily identified, although the incidence among contacts and the relative risk for them appear to vary considerably in different studies. In incidence studies, infection rates for contacts of lepromatous leprosy have varied from 6.2 per 1000 per year in Cebu, Philippines[37] to 55.8 per 1000 per year in a part of Southern India.[38]
Two exit routes of M. leprae from the human body often described are the skin and the nasal mucosa, although their relative importance is not clear. Lepromatous cases show large numbers of organisms deep in the dermis, but whether they reach the skin surface in sufficient numbers is doubtful. Although there are reports of acid-fast bacilli being found in the desquamating epithelium (sloughing of superficial layer of skin) of the skin, Weddell et al. had reported in 1963 that they could not find any acid-fast bacilli in the epidermis, even after examining a very large number of specimens from patients and contacts.[39] In a recent study, Job et al. found fairly large numbers of M. leprae in the superficial keratin layer of the skin of lepromatous leprosy patients, suggesting that the organism could exit along with the sebaceous secretions.[40]
The importance of the nasal mucosa was recognized as early as 1898 by Schäffer, particularly that of the ulcerated mucosa.[41] The quantity of bacilli from nasal mucosal lesions in lepromatous leprosy was demonstrated by Shepard as large, with counts ranging from 10,000 to 10,000,000.[42] Pedley reported that the majority of lepromatous patients showed leprosy bacilli in their nasal secretions as collected through blowing the nose.[43] Davey and Rees indicated that nasal secretions from lepromatous patients could yield as much as 10 million viable organisms per day.[44]
The entry route of M. leprae into the human body is also not definitively known: the skin and the upper respiratory tract are most likely. While older research dealt with the skin route, recent research has increasingly favored the respiratory route. Rees and McDougall succeeded in the experimental transmission of leprosy through aerosols containing M. leprae in immune-suppressed mice, suggesting a similar possibility in humans.[45] Successful results have also been reported on experiments with nude mice when M. leprae were introduced into the nasal cavity by topical application.[46] In summary, entry through the respiratory route appears the most probable route, although other routes, particularly broken skin, cannot be ruled out. The CDC notes the following assertion about the transmission of the disease: "Although the mode of transmission of Hansen's disease remains uncertain, most investigators think that M. leprae is usually spread from person to person in respiratory droplets."[47]
In leprosy both the reference points for measuring the incubation period and the times of infection and onset of disease are difficult to define; the former because of the lack of adequate immunological tools and the latter because of the disease's slow onset. Even so, several investigators have attempted to measure the incubation period for leprosy. The minimum incubation period reported is as short as a few weeks and this is based on the very occasional occurrence of leprosy among young infants.[48] The maximum incubation period reported is as long as 30 years, or over, as observed among war veterans known to have been exposed for short periods in endemic areas but otherwise living in non-endemic areas. It is generally agreed that the average incubation period is between three and five years.
Prevention
Venezuelan Dr. Jacinto Convit synthesized a vaccine from the tuberculosis vaccine and the Mycobacterium leprae, a feat which earned him a nomination for the Nobel prize in medicine in the late 1990s.
In a recent trial, a single dose of rifampicin reduced the rate at which contacts acquired leprosy in the two years after contact by 57%; 265 treatments with rifampicin prevented one case of leprosy in this period.[49] A non-randomized study found that rifampicin reduced the number of new cases of leprosy by 75% after three years.[50]
BCG offers a variable amount of protection against leprosy as well as against tuberculosis.[51][52]
Efforts to overcome persistent obstacles to the elimination of the disease include improving detection, educating patients and the population about its cause, and fighting social taboos about a disease whose patients have historically been considered "unclean" or "cursed by God" as outcasts. Leprosy is not a heredity disease. Where taboos are strong, patients may be forced to hide their condition (and avoid seeking treatment) to avoid discrimination. The lack of awareness about Hansen's disease can lead people to believe (falsely) that the disease is highly contagious and incurable.
The ALERT hospital and research facility in Ethiopia provides training to medical personnel from around the world in the treatment of leprosy, as well as treating many local patients. Surgical techniques, such as for the restoration of control of movement of thumbs, have been developed.
Treatment
![](http://upload.wikimedia.org/wikipedia/commons/thumb/7/71/MDTRegimens.jpg/220px-MDTRegimens.jpg)
The WHO Study Group's report on the Chemotherapy of Leprosy in 1993 recommended two types of standard MDT regimen be adopted.[53] The first was a 24-month treatment for multibacillary (MB or lepromatous) cases using rifampicin, clofazimine, and dapsone. The second was a six-month treatment for paucibacillary (PB or tuberculoid) cases, using rifampicin and dapsone. At the First International Conference on the Elimination of Leprosy as a Public Health Problem, held in Hanoi the next year, the global strategy was endorsed and funds provided to WHO for the procurement and supply of MDT to all endemic countries.
Between 1995 and 1999, WHO, with the aid of the Nippon Foundation (Chairman Yōhei Sasakawa, World Health Organization Goodwill Ambassador for Leprosy Elimination), supplied all endemic countries with free MDT in blister packs, channelled through Ministries of Health. This free provision was extended in 2000 with a donation by the MDT manufacturer Novartis, which will run until at least the end of 2010. At the national level, non-government organizations (NGOs) affiliated to the national programme will continue to be provided with an appropriate free supply of this WHO supplied MDT by the government.
MDT remains highly effective, and patients are no longer infectious after the first monthly dose.[7] It is safe and easy to use under field conditions due to its presentation in calendar blister packs.[7] Relapse rates remain low, and there is no known resistance to the combined drugs.[7] The Seventh WHO Expert Committee on Leprosy,[54] reporting in 1997, concluded that the MB duration of treatment—then standing at 24 months—could safely be shortened to 12 months "without significantly compromising its efficacy."
Current recommendations
- Pauci-bacillary leprosy (1-5 skin lesions) Treat with rifampicin and dapsone for 6 months
- Multi-bacillary leprosy (>5 skin lesions) Treat with rifampicin, clofazimine and dapsone for 12 months
Historical treatments
The disease was known in Ancient Greece as elephantiasis (elephantiasis graecorum). The Bible (Mathew 11,5) suggested that leprosy was curable by supernatural means and the practice of laying on of hands or of relics developed from this. Saint Giles, Saint Martin, Saint Maxillian and Saint Roman were associated with this practice. Several monarchs were also associated with this practice: among these were Elizabeth I , Henry III of England and Charlemagne.
At various times blood was considered to be a treatment either as a beverage or as a bath. That of virgins or children was considered to be especially potent. This practice seems to have originated with the Ancient Egyptians but was also known in China where people were murdered for their blood. This practice persisted until at least 1790 when the use of dog blood was mentioned in De Secretis Naturae. Paracelsus recommended the use of lamb's blood and even blood from dead bodies was used.
Snakes were also used, according to Pliny, Areteus of Capadocia and Theodorus. Gaucher recommended treatment with cobra venom. Boinet, in 1913, tried increasing doses of bee stings (up to 4000). Scorpions and frogs were used occasionally instead of snakes. The excreta of Anabas (the climbing fish) was also tried.
Alternative treatments included scarification with or without the addition of irritants including arsenic and hellebore. Castration was also practiced in the Middle Ages.
- Chaulmoogra oil
A common pre-modern treatment of leprosy was chaulmoogra oil. One Indian legend relates that Rama acquired leprosy and was cured by eating the fruit of the Kalaw (a species of the genusHydnocarpus) tree. He went on to cure the princess Piya with the same fruit and the pair returned to Benares to spread the word of their discovery.
The oil has long been used in India as an Ayurvedic medicine for the treatment of leprosy and various skin conditions. It has also been used in China and Burma, and was introduced to the West by Frederic John Mouat, a professor at Bengal Medical College. He tried the oil as an oral and topical agent in two cases of leprosy and reported significant improvements in an 1854 paper.[55]
This paper caused some confusion. Mouat indicated that the oil was the product of a tree Chaulmoogra odorata which had been described in 1815 by William Roxburgh, a surgeon and naturalist, while he was cataloging the plants in the East India Company’s botanical garden in Calcutta. This tree is also known as Gynocardia odorata. For the rest of the 19th century this tree was thought to be the source of the oil. In 1901 Sir David Prain identified the true chaulmoogra seeds of the Calcutta bazaar and of the Paris and London apothecaries as coming from Taraktogenos kurzii which is found in Burma and Northeast India. The oil mentioned in the Ayurvedic texts was from the tree Hydnocarpus wightiana known as Tuvakara in Sanskrit and chaulmugra in Hindi and Persian.
The first parenteral administration was given by the Egyptian doctor Tortoulis Bey, personal physician to the Sultan Hussein Kamel. He had been using subcutaneous injections of creosite for tuberculosis and in 1894 administered subcutaneous injection of chaulmoogra oil in a 36-year old Egyptian Copt who had been unable to tolerate oral treatment. After 6 years and 584 injections the patient was declared cured.
An early scientific analysis of the oil was carried out by Frederick B. Power in London in 1904. He and his colleagues isolated a new unsaturated fatty acid from the seeds which they named 'chaulmoogric acid'. They also investigated two closely related species: Hydnocarpus anthelmintica and Hydnocarpus wightiana. From these two trees they isolated both chaulmoogric acid and a closely related compound, 'hydnocarpus acid'. They also investigated Gynocardia odorata and found that it produced neither of these acids. Later investigation showed that 'taraktogenos' (Hydnocarpus kurzii) also produced chaulmoogric acid.
Another difficulty with the use of this oil was administration. Taken orally it is extremely nauseating. Given by enema may cause peri-anal ulcers and fissures. Given by injection the drug caused fever and other local reactions. Despite these difficulties a series of 170 patients were reported in 1916 by Ralph Hopkins, the attending physician at the Louisiana Leper Home inCarville, Louisiana. He divided the patients into two groups - 'incipient' and 'advanced'. In the advanced cases at most a quarter showed any improvement or arrest of their condition. In the incipient cases he reported an improvement or stabilization of the disease in 45%; 4% died and 8% died. The remainder absconded from the Home apparently in improved condition.
Given the apparent usefulness of this agent, a search began for improved formulations. Victor Heiser the Chief Quarantine Officer and Director of Health for Manila and Elidoro Mercadothe house physician at the San Lazaro Hospital for lepers in Manila decided to add camphor to a prescription of chaulmoogra and resorcin which was typically given orally at the suggestion of Merck and Company in Germany to whom Heiser had written. They found that this new compound was readily absorbed without the nausea that had plagued the earlier preparations.
Heiser and Mercado in 1913 then administered the oil by injection to two patients who were apparently cured of the disease. Since this treatment was administered in conjunction with other materials the results were not clear. A further two patients were treated with the oil by injection without other treatments and again appeared to be cured of the disease. The following year Heiser reported a further 12 patients but the results were mixed.
Less toxic injectable forms of this oil were then sought. Between 1920 and 1922 a series of papers were published describing the esters of these oils. These may have been based on the work of Alice Ball - the record is not clear on this point and Ms Ball died in 1916. Trials of these esters were carried out in 1921 and appeared to give useful results.
These attempts had been preceded by others. Merck of Darmstadt had produced a version of the sodium salts in 1891. They named this sodium gynocardate in the mistaken belief that the origin of the oil was Gynocardia odorata. Bayer in 1908 marketed a commercial version of the esters under the name 'Antileprol'.
To ensure a supply of this agent Joseph Rock, Professor of Systematic Botany at the College of Hawaii, traveled to Burma. The local villagers located a grove of trees in seed which he used to establish a plantation in 2,980 trees on the island of Oahu, Hawaii between 1921 and 1922.
The oil remained a popular treatment despite the common side effects until the introduction of sulfones in the 1940s. Debate about its efficacy continued until it was discontinued.
![](http://upload.wikimedia.org/wikipedia/commons/0/00/Multidrug_therapy_%28MDT%29_for_the_treatment_of_leprosy.jpg)
Promin was first synthesised in 1908 by Emil Fromm, professor of chemistry at Albert-Ludwig University in Freiburg im Breisgau, Germany. Its anti strepococcal activity was investigated by Gladstone Buttle at Burroughs Wellcome and Ernest Fourneau at the Institut Pasteur.
Until the development of promin in the 1940s, there was no effective treatment for leprosy. The efficacy of promin was first discovered by Guy Henry Faget and his co-workers in 1943 at Carville, Louisiana. In the 1950s dapsone was introduced to Carville by Dr. R.G. Cochrane. It is only weakly bactericidal against M. leprae and it was considered necessary for patients to take the drug indefinitely. When dapsone was used alone, the M. lepraepopulation quickly evolved antibiotic resistance; by the 1960s, the world's only known anti-leprosy drug became virtually useless.
The search for more effective anti-leprosy drugs led to the use of clofazimine and rifampicinin the 1960s and 1970s.[56] Later, Indian scientist Shantaram Yawalkar and his colleagues formulated a combined therapy using rifampicin and dapsone, intended to mitigate bacterial resistance.[57] The first trials of combined treatment were carried out in Malta in the 1970s.
Multidrug therapy (MDT) combining all three drugs was first recommended by a WHO Expert Committee in 1981. These three anti-leprosy drugs are still used in the standard MDT regimens. None of them is used alone because of the risk of developing resistance.
This treatment was quite expensive, and was not quickly adopted in most endemic countries. In 1985 leprosy was still considered a public health problem in 122 countries. The 44th World Health Assembly (WHA), held in Geneva in 1991, passed a resolution to eliminate leprosy as a public-health problem by the year 2000—defined as reducing the global prevalence of the disease to less than 1 case per 10,000. At the Assembly, the World Health Organization (WHO) was given the mandate to develop an elimination strategy by its member states, based on increasing the geographical coverage of MDT and patients’ accessibility to the treatment.
Epidemiology
![](http://upload.wikimedia.org/wikipedia/commons/thumb/9/91/Lepra_2003.png/220px-Lepra_2003.png)
![](http://upload.wikimedia.org/wikipedia/commons/thumb/7/7b/Leprosy_world_map_-_DALY_-_WHO2002.svg/220px-Leprosy_world_map_-_DALY_-_WHO2002.svg.png)
Worldwide, two to three million people are estimated to be permanently disabled because of leprosy.[9] India has the greatest number of cases, with Brazil second and Burma third.
In 1999, the world incidence of Hansen's disease was estimated to be 640,000. In 2000, 738,284 cases were identified.[59] In 2000, the World Health Organization (WHO) listed 91 countries in which Hansen's disease is endemic. India, Myanmar and Nepal contained 70% of cases. India reports over 50% of the world's leprosy cases.[60] In 2002, 763,917 new cases were detected worldwide, and in that year the WHO listed Brazil, Madagascar, Mozambique, Tanzania and Nepal as having 90% of Hansen's disease cases.
According to recent figures from the WHO, new cases detected worldwide have decreased by approximately 107,000 cases (or 21%) from 2003 to 2004. This decreasing trend has been consistent for the past three years. In addition, the global registered prevalence of HD was 286,063 cases; 407,791 new cases were detected during 2004.
In the United States, Hansen's disease is tracked by the Centers for Disease Control and Prevention (CDC), with a total of 92 cases being reported in 2002.[61] Although the number of cases worldwide continues to fall, pockets of high prevalence continue in certain areas such as Brazil, South Asia (India, Nepal), some parts of Africa (Tanzania, Madagascar, Mozambique) and the western Pacific.
Risk groups
At highest risk are those living in endemic areas with poor conditions such as inadequate bedding, contaminated water and insufficient diet, or other diseases (such as HIV) that compromise immune function. Recent research suggests that there is a defect in cell-mediated immunity that causes susceptibility to the disease. Less than ten percent of the world's population is actually capable of acquiring the disease.[62] The region of DNA responsible for this variability is also involved in Parkinson disease,[citation needed] giving rise to current speculation that the two disorders may be linked in some way at the biochemical level. In addition, men are twice as likely to contract leprosy as women.[citation needed] According to The Leprosy Mission Canada, most people-–about 95% of the population-–are naturally immune.[62]
Disease burden
Although annual incidence—the number of new leprosy cases occurring each year—is important as a measure of transmission, it is difficult to measure in leprosy due to its long incubation period, delays in diagnosis after onset of the disease and the lack of laboratory tools to detect leprosy in its very early stages. Instead, the registered prevalence is used. Registered prevalence is a useful proxy indicator of the disease burden as it reflects the number of active leprosy cases diagnosed with the disease and receiving treatment with MDT at a given point in time. The prevalence rate is defined as the number of cases registered for MDT treatment among the population in which the cases have occurred, again at a given point in time.[63]
New case detection is another indicator of the disease that is usually reported by countries on an annual basis. It includes cases diagnosed with onset of disease in the year in question (true incidence) and a large proportion of cases with onset in previous years (termed a backlog prevalence of undetected cases).
Endemic countries also report the number of new cases with established disabilities at the time of detection, as an indicator of the backlog prevalence. Determination of the time of onset of the disease is generally unreliable, is very labor-intensive and is seldom done in recording these statistics.
Global situation
Region | Registered prevalence (rate/10,000 pop.) |
New case detection during the year | ||||
---|---|---|---|---|---|---|
Start of 2006 | 2001 | 2002 | 2003 | 2004 | 2005 | |
Africa | 40,830 (0.56) | 39,612 | 48,248 | 47,006 | 46,918 | 42,814 |
Americas | 32,904 (0.39) | 42,830 | 39,939 | 52,435 | 52,662 | 41,780 |
South-East Asia | 133,422 (0.81) | 668,658 | 520,632 | 405,147 | 298,603 | 201,635 |
Eastern Mediterranean | 4,024 (0.09) | 4,758 | 4,665 | 3,940 | 3,392 | 3,133 |
Western Pacific | 8,646 (0.05) | 7,404 | 7,154 | 6,190 | 6,216 | 7,137 |
Totals | 219,826 | 763,262 | 620,638 | 514,718 | 407,791 | 296,499 |
Countries | Registered prevalence (rate/10,000 pop.) |
New case detection (rate/100,000 pop.) | ||||
---|---|---|---|---|---|---|
Start of 2004 | Start of 2005 | Start of 2006 | During 2003 | During 2004 | During 2005 | |
![]() |
79,908 (4.6) | 30,693 (1.7) | 27,313 (1.5) | 49,206 (28.6) | 49,384 (26.9) | 38,410 (20.6) |
![]() |
6,810 (3.4) | 4,692 (2.4) | 4,889 (2.5) | 5,907 (29.4) | 4,266 (22.0) | 5,371 (27.1) |
![]() |
7,549 (3.1) | 4,699 (1.8) | 4,921 (1.8) | 8,046 (32.9) | 6,958 (26.2) | 6,150 (22.7) |
![]() |
5,420 (1.6) | 4,777 (1.3) | 4,190 (1.1) | 5,279 (15.4) | 5,190 (13.8) | 4,237 (11.1) |
Totals | NA | NA | NA | NA | NA | NA |
As reported to WHO by 115 countries and territories in 2006, and published in the Weekly Epidemiological Record the global registered prevalence of leprosy at the beginning of the year was 219,826 cases.[64] New case detection during the previous year (2005 - the last year for which full country information is available) was 296,499. The reason for the annual detection being higher than the prevalence at the end of the year can be explained by the fact that a proportion of new cases complete their treatment within the year and therefore no longer remain on the registers. The global detection of new cases continues to show a sharp decline, falling by 110,000 cases (27%) during 2005 compared with the previous year.
Table 1 shows that global annual detection has been declining since 2001. The African region reported an 8.7% decline in the number of new cases compared with 2004. The comparable figure for the Americas was 20.1%, for South-East Asia 32% and for the Eastern Mediterranean it was 7.6%. The Western Pacific area, however, showed a 14.8% increase during the same period.
Table 2 shows the leprosy situation in the four major countries which have yet to achieve the goal of elimination at the national level. It should be noted that: a) Elimination is defined as a prevalence of less than 1 case per 10,000 population; b) Madagascar reached elimination at the national level in September 2006; c) Nepal detection reported from mid-November 2004 to mid-November 2005; and d) D.R. Congo officially reported to WHO in 2008 that it had reached elimination by the end of 2007, at the national level.
Current situation in the People's Republic of China
The People's Republic of China has many leprosy recovered patients who have been isolated from the rest of society. In the 1950s the Chinese Communist government created "Recovered Villages" in rural remote mountaintops for the recovered patients. Although leprosy is now curable with the advent of the multi-drug treatment, the villagers remain because they have been stigmatized by the outside world. Health NGOs such as Joy in Action have arisen in China to especially focus on improving the conditions of "Recovered Villages".
History
Etymology
The word leprosy comes from ancient Greek λέπρα [léprā], "a disease which makes the skin scaly", in turn a nominal derivation of the verb λέπω [lépō], "to peel, scale off". The word came into the English language via Latin and Old French. The first attested English use is in the Ancrene Wisse, a 13th-century manual for nuns ("Moyseses hond..bisemde o þe spitel uuel & þuhte lepruse." The Middle English Dictionary, s.v., "leprous"). A roughly contemporaneous use is attested in the Anglo-Norman Dialogues of Saint Gregory, "Esmondez i sont li lieprous" (Anglo-Norman Dictionary, s.v., "leprus").
Historically, individuals with Hansen's disease have been known as lepers; however, this term is falling into disuse as a result of the diminishing number of leprosy patients and the pejorative connotations of the term.[citation needed] Because of the stigma to patients, some prefer not to use the word "leprosy," though the term is used by the U.S. Centers for Disease Control and Prevention and the World Health Organization.[citation needed]
Historically, the term Tzaraath from the Hebrew Bible was, erroneously, commonly translated as leprosy, although the symptoms of Tzaraath were not entirely consistent with leprosy and rather referred to a variety of disorders other than Hansen's disease.[65] The first mention of leprosy recorded is found in Leviticus 13:2 - "When a man shall have in the skin of his flesh a rising, a scab, or bright spot, and it be in the skin of his flesh like the plague of leprosy; then he shall be brought unto Aaron the priest, or unto one of his sons the priests." There is also the well known Bible story of the Syrian Naaman, "captain of the host of the king of Syria" (2 Kings 5:1), who suffered from this severe and savage skin disease.
In particular, tinea capitis (fungal scalp infection) and related infections on other body parts caused by the dermatophyte fungus Trichophyton violaceum are abundant throughout the Middle East and North Africa today and might also have been common in biblical times. Similarly, the related agent of the disfiguring skin disease favus, Trichophyton schoenleinii, appears to have been common throughout Eurasia and Africa before the advent of modern medicine. Persons with severe favus and similar fungal diseases (and potentially also with severe psoriasis and other diseases not caused by microorganisms) tended to be classed as having leprosy as late as the 17th century in Europe.[66] This is clearly shown in the painting The Regents of the Leper Hospital in Haarlem 1667 by Jan de Bray (Frans Hals Museum, Haarlem, the Netherlands), where a young Dutchman with a vivid scalp infection, almost certainly caused by a fungus, is shown being cared for by three officials of a charitable home intended for leprosy sufferers.[citation needed] The use of the word "leprosy" before the mid-19th century, when microscopic examination of skin for medical diagnosis was first developed, can seldom be correlated reliably with Hansen's disease as we understand it today.[citation needed]
Identification of the causative organism
![](http://upload.wikimedia.org/wikipedia/commons/thumb/5/53/Gerhard_Armauer_Hansen.jpg/220px-Gerhard_Armauer_Hansen.jpg)
After the end of the 17th century, Norway and Iceland were the only countries in Western Europe where leprosy was a significant problem. During the 1830s, the number of lepers in Norway rose rapidly, causing an increase in medical research into the condition, and the disease became a political issue. Norway appointed a medical superintendent for leprosy in 1854 and established a national register for lepers in 1856, the first national patient register in the world.[67]
Mycobacterium leprae, the causative agent of leprosy, was discovered by G. H. Armauer Hansen in Norway in 1873, making it the first bacterium to be identified as causing disease in humans.[68][69]
Hansen observed a number of non refractile small rods in unstained tissue sections. The rods were not soluble in potassium lye and they were acid and alcohol fast. In 1879 he was able to stain these organisms with Ziehl's method and the similarities with Koch's bacillus (Mycobacterium tuberculosis) were noted. There were three significant differences between these organisms: (1) the rods in the leprosy lesions were extremely numerous (2) they formed characteristic intracellular collections (globii) and (3) the rods had a variety of shapes with branching and swelling. These differences suggested that leprosy was caused by an organism related to but distinct from Mycobacterium tuberculosis.
He worked at St. Jørgens Hospital in Bergen, founded early in the fifteenth century. St. Jørgens is today a museum, Lepramuseet, probably the best preserved leprosy hospital in Northern Europe.[70]
Rome
In the West, the earliest known description of leprosy there was made by the Roman encyclopedist Aulus Cornelius Celsus (25 BC – 37 AD) in his De Medicina; he called leprosy "elephantiasis".[71] The Roman author Pliny the Elder (23–79 AD) mentioned the same disease.[71] Although "sara't" of Leviticus (Old Testament) is translated as "lepra" in the 5th century AD Vulgate, the original term sara't found in Leviticus was not the elephantiasis described by Celsus and Pliny; in fact, sara't was used to describe a disease which could affect houses and clothing.[71] Katrina C. D. McLeod and Robin D. S. Yates state that sara't "denotes a condition of ritual impurity or a temporary form of skin disease."[71]
Muslim world
In the Muslim world, the Persian polymath Avicenna (c. 980–1037) was the first outside of China to describe the destruction of the nasal septum in those suffering from leprosy.[71]
Middle Ages
Numerous leprosaria, or leper hospitals, sprang up in the Middle Ages; Matthew Paris, a Benedictine Monk, estimated that in the early thirteenth century there were 19,000 across Europe.[72] The first recorded Leper colony was in Harbledown. These institutions were run along monastic lines and, while lepers were encouraged to live in these monastic-type establishments, this was for their own health as well as quarantine. Indeed, some medieval sources indicate belief that those suffering from leprosy were considered to be going through Purgatory on Earth, and for this reason their suffering was considered holier than the ordinary person's. More frequently, lepers were seen to exist in a place between life and death: they were still alive, yet many chose or were forced to ritually separate themselves from mundane existence.[73] The Order of Saint Lazarus was a hospitaller and military order of monks that began as a leper hospital outside Jerusalem in the twelfth century and remained associated with leprosy throughout its history. The first monks in this order were leper knights and they originally had leper grand masters, although these aspects of the order changed over the centuries.
Radegund was noted for washing the feet of lepers. Orderic Vitalis writes of a monk, Ralf, who was so overcome by the plight of lepers that he prayed to catch leprosy himself (which he eventually did). The leper would carry a clapper and bell to warn of his approach, and this was as much to attract attention for charity as to warn people that a diseased person was near.
India
The Oxford Illustrated Companion to Medicine holds that the mention of leprosy, as well as cures for it, were already described in the Hindu religious book Atharva-veda.[74] Writing in the Encyclopedia Britannica 2008, Kearns & Nash state that the first mention of leprosy is in the Indian medical treatise Sushruta Samhita (6th century BC).[75] The Cambridge Encyclopedia of Human Paleopathology (1998) holds that: "The Sushruta Samhita from India describes the condition quite well and even offers therapeutic suggestions as early as about 600 BC"[76] The surgeon Sushruta lived in the Indian city of Kashi by the 6th century BC,[77] and the medical treatise Sushruta Samhita—attributed to him—made its appearance during the 1st millennium BC.[75] The earliest surviving excavated written material which contains the works of Sushruta is the Bower Manuscript—dated to the 4th century AD, almost a millennium after the original work.[78] Despite the existence of these earlier works the first generally considered accurate description of the disease was that of Galen of Pergamum in 150 AD.
In 2009, a 4,000-year-old skeleton was uncovered in India that was shown to contain traces of leprosy.[79] The discovery was made at a site called Balathal, which is today part of Rajasthan, and is believed[by whom?] to be the oldest case of the disease ever found.[80] This pre-dated the previous earliest recognized case, dating back to 6th-century Egypt, by 1,500 years.[81] It is believed that the excavated skeleton belonged to a male, who was in his late 30s and belonged to the Ahar Chalcolithic culture.[81][82] Archaeologists have stated that not only does the skeleton represent the oldest case of leprosy ever found, but is also the first such example that dates back to prehistoric India.[83] This finding supports one of the theories regarding the origin of the disease, which is believed to have originated in either India or Africa, before being subsequently spread to Europe by the armies of Alexander the Great.[80]
In 1881, around 120,000 leprosy patients existed in India. The central government passed the Lepers Act of 1898, which provided legal provision for forcible confinement of leprosy sufferers in India.[84]
China
Regarding ancient China, Katrina C. D. McLeod and Robin D. S. Yates identify the State of Qin's Feng zhen shi 封診式 (Models for sealing and investigating), dated 266-246 BC, as offering the earliest known unambiguous description of the symptoms of low-resistance leprosy, even though it was termed then under li 癘, a general Chinese word for skin disorder.[71] This 3rd century BC Chinese text on bamboo slip, found in an excavation of 1975 at Shuihudi, Yunmeng, Hubei province, not only described the destruction of the "pillar of the nose", but also the "swelling of the eyebrows, loss of hair, absorption of nasal cartilage, affliction of knees and elbows, difficult and hoarse respiration, as well as anesthesia."[71]
Japan
Japan has had a unique history of segregation of patients into sanatoriums based on leprosy prevention laws of 1907, 1931 and 1953, and hence, it intensified leprosy stigma. The 1953 law was abrogated in 1996. There are still 2717 ex-patients in 13 national sanatoriums and 2 private hospitals as of 2008. In a document written in 833, leprosy was described as "caused by a parasite which eats five organs of the body. The eyebrows and eyelashes come off, and the nose is deformed. The disease brings hoarseness, and necessitates amputations of the fingers and toes. Do not sleep with the patients, as the disease is transmittable to those nearby." This was the first document concerning infectivity.[85]
Society and culture
Notable cases
- Baldwin IV, who was a king of Latin Jerusalem and was portrayed as a character in the film Kingdom of Heaven[86]
- Vietnamese poet Han Mac Tu[87]
- Probably not Robert the Bruce although one English source said that he did. [88] In the 1995 Mel Gibson film Braveheart, Robert the Bruce's father - Robert de Brus, 6th Lord of Annandale - is depicted as having leprosy.
- Otani Yoshitsugu, a Japanese daimyo[89]
- Biblical writings have a number of references such as Moses's sister,[90] Moses,[91] commander of the army of Syria Naaman the Syrian and later the prophet Elisha's servant Gehazi,[92] and several people Jesus healed,[93] [94] though the afflictions mentioned and symptoms described are now thought not to be, or not exclusively to be, the result of Hansen's Disease (see discussion at 'Tzaraath').
See also
References
- ^ Sasaki S, Takeshita F, Okuda K, Ishii N (2001). "Mycobacterium leprae and leprosy: a compendium". Microbiol Immunol. 45 (11): 729–36. PMID 11791665.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ a b c "New Leprosy Bacterium: Scientists Use Genetic Fingerprint To Nail 'Killing Organism'". ScienceDaily. 2008-11-28. Retrieved 2010-01-31.
- ^ a b c Kenneth J. Ryan, C. George Ray, editors. (2004). Ryan KJ, Ray CG (ed.). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 451–3. ISBN 0838585299. OCLC 52358530 61405904.
{{cite book}}
:|author=
has generic name (help); Check|oclc=
value (help)CS1 maint: multiple names: authors list (link) - ^ a b "Lifting the stigma of leprosy: a new vaccine offers hope against an ancient disease". Time. 119 (19): 87. 1982. PMID 10255067.
{{cite journal}}
: Unknown parameter|month=
ignored (help) - ^ Kulkarni GS (2008). Textbook of Orthopedics and Trauma (2 ed.). Jaypee Brothers Publishers. p. 779. ISBN 8184482426, 9788184482423.
{{cite book}}
: Check|isbn=
value: invalid character (help) - ^ Holden (2009). "Skeleton Pushes Back Leprosy's Origins". ScienceNOW. Retrieved 2010-01-31.
- ^ a b c d e f "Leprosy". WHO. 2009-08-01. Retrieved 2010-01-31.
- ^ "DNA of Jesus-Era Shrouded Man in Jerusalem Reveals Earliest Case of Leprosy". ScienceDaily. 2009-12-16. Retrieved 2010-01-31.
- ^ a b WHO (1995). "Leprosy disabilities: magnitude of the problem". Weekly Epidemiological Record. 70 (38): 269–75. PMID 7577430.
- ^ a b Walsh F (2007-03-31). "The hidden suffering of India's lepers". BBC News.
- ^ Lyn TE (2006-09-13). "Ignorance breeds leper colonies in China". Independat News & Media. Retrieved 2010-01-31.
- ^ Radan S, Hutt A (2001-11-06). "Europe's last leper colony lives on". BBC News. Retrieved 2010-01-31.
- ^ ""Making Peace With Vietnam" to be screened at Beijing film festival". Radio the Voice of Vietnam. 2009-02-08. Retrieved 2010-01-31.
- ^ Japan repealed its "Leprosy Prevention Laws" in 1996 but former patients still reside in sanatoriums. "Koizumi apologises for leper colonies". BBC News. May 25, 2001. and Ex-Hansen's disease patients still struggling with prejudice Japan Times June 7, 2007.
- ^ Syphilis through history Encyclopædia Britannica
- ^ "About leprosy: frequently asked questions". American Leprosy Missions, Inc. Retrieved September 19, 2009.
- ^ Jopling WH (1991). "Leprosy stigma". Lepr Rev. 62 (1): 1–12. PMID 2034017.
{{cite journal}}
: Unknown parameter|month=
ignored (help) - ^ a b "Communicable Diseases Department, Leprosy FAQ". World Health Organization. 2006-05-25. Retrieved 2010-01-31.
- ^ Smith DS (2008-08-19). "Leprosy: Overview". eMedicine Infectious Diseases. Retrieved 2010-02-01.
- ^ Singh N, Manucha V, Bhattacharya SN, Arora VK, Bhatia A (2004). "Pitfalls in the cytological classification of borderline leprosy in the Ridley-Jopling scale". Diagn. Cytopathol. 30 (6): 386–8. doi:10.1002/dc.20012. PMID 15176024.
{{cite journal}}
:|access-date=
requires|url=
(help); Unknown parameter|month=
ignored (help)CS1 maint: multiple names: authors list (link) - ^ Ridley DS, Jopling WH (1966). "Classification of leprosy according to immunity. A five-group system". Int. J. Lepr. Other Mycobact. Dis. 34 (3): 255–73. PMID 5950347.
{{cite journal}}
:|access-date=
requires|url=
(help) - ^ Modlin RL (1994). "Th1-Th2 paradigm: insights from leprosy". J. Invest. Dermatol. 102 (6): 828–32. doi:10.1111/1523-1747.ep12381958. PMID 8006444.
{{cite journal}}
: Unknown parameter|month=
ignored (help) - ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
{{cite book}}
: Explicit use of et al. in:|author=
(help)CS1 maint: multiple names: authors list (link) - ^ Jardim MR, Antunes SL, Santos AR; et al. (2003). "Criteria for diagnosis of pure neural leprosy". J. Neurol. 250 (7): 806–9. doi:10.1007/s00415-003-1081-5. PMID 12883921.
{{cite journal}}
: Explicit use of et al. in:|author=
(help); Unknown parameter|month=
ignored (help)CS1 maint: multiple names: authors list (link) - ^ Mendiratta V, Khan A, Jain A (2006). "Primary neuritic leprosy: a reappraisal at a tertiary care hospital". Indian J Lepr. 78 (3): 261–7. PMID 17120509.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ Ishida Y, Pecorini L, Guglielmelli E (2000). "Three cases of pure neuritic (PN) leprosy at detection in which skin lesions became visible during their course". Nihon Hansenbyo Gakkai Zasshi. 69 (2): 101–6. PMID 10979277.
{{cite journal}}
: Unknown parameter|month=
ignored (help)CS1 maint: multiple names: authors list (link) - ^ Mishra B, Mukherjee A, Girdhar A, Husain S, Malaviya GN, Girdhar BK (1995). "Neuritic leprosy: further progression and significance". Acta Leprol. 9 (4): 187–94. PMID 8711979.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ Talwar S, Jha PK, Tiwari VD (1992). "Neuritic leprosy: epidemiology and therapeutic responsiveness". Lepr Rev. 63 (3): 263–8. PMID 1406021.
{{cite journal}}
: Unknown parameter|month=
ignored (help)CS1 maint: multiple names: authors list (link) - ^ Kulkarni GS (2008). Textbook of Orthopedics and Trauma (2 ed.). Jaypee Brothers Publishers. p. 779. ISBN 8184482426, 9788184482423.
{{cite book}}
: Check|isbn=
value: invalid character (help) - ^ McMurray DN (1996). Mycobacteria and Nocardia. in: Baron's Medical Microbiology (Baron S et al., eds.) (4th ed.). Univ of Texas Medical Branch. ISBN 0-9631172-1-1. OCLC 33838234.
- ^ Bhattacharya S, Vijayalakshmi N, Parija SC (1 October 2002). "Uncultivable bacteria: Implications and recent trends towards identification". Indian journal of medical microbiology. 20 (4): 174–7. PMID 17657065.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ Rojas-Espinosa O, Løvik M (2001). "Mycobacterium leprae and Mycobacterium lepraemurium infections in domestic and wild animals". Rev. - Off. Int. Epizoot. 20 (1): 219–51. PMID 11288514.
- ^ Hastings RC, Gillis TP, Krahenbuhl JL, Franzblau SG (1988-07-01). "Leprosy". Clin. Microbiol. Rev. 1 (3): 330–48. PMC 358054. PMID 3058299.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ Alcaïs A, Mira M, Casanova JL, Schurr E, Abel L (2005). "Genetic dissection of immunity in leprosy". Curr. Opin. Immunol. 17 (1): 44–8. doi:10.1016/j.coi.2004.11.006. PMID 15653309.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ "AR Dept of Health debunks leprosy fears". 2008-02-08. Retrieved 2008-04-08.
- ^ Kaur H, Van Brakel W (2002). "Dehabilitation of leprosy-affected people—a study on leprosy-affected beggars". Leprosy review. 73 (4): 346–55. PMID 12549842.
- ^ Doull JA, Guinto RA, Rodriguez RS; et al. (1942). "The incidence of leprosy in Cordova and Talisay, Cebu, Philippines". International Journal of Leprosy. 10: 107–131.
{{cite journal}}
: Explicit use of et al. in:|author=
(help)CS1 maint: multiple names: authors list (link) - ^ Noordeen S, Neelan P (1978). "Extended studies on chemoprophylaxis against leprosy". Indian J Med Res. 67: 515–27. PMID 355134.
- ^ Weddell G, Palmer E (1963). "The pathogenesis of leprosy. An experimental approach". Leprosy Review. 34: 57–61. PMID 13999438.
- ^ Job C, Jayakumar J, Aschhoff M (1999). ""Large numbers" of Mycobacterium leprae are discharged from the intact skin of lepromatous patients; a preliminary report". Int J Lepr Other Mycobact Dis. 67 (2): 164–7. PMID 10472371.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ Arch Dermato Syphilis 1898; 44:159–174
- ^ Shepard C (1960). "Acid-fast bacilli in nasal excretions in leprosy, and results of inoculation of mice". Am J Hyg. 71: 147–57. PMID 14445823.
- ^ Pedley J (1973). "The nasal mucus in leprosy". Lepr Rev. 44 (1): 33–5. PMID 4584261.
- ^ Davey T, Rees R (1974). "The nasal dicharge in leprosy: clinical and bacteriological aspects". Lepr Rev. 45 (2): 121–34. PMID 4608620.
- ^ Rees R, McDougall A (1977). "Airborne infection with Mycobacterium leprae in mice". J Med Microbiol. 10 (1): 63–8. doi:10.1099/00222615-10-1-63. PMID 320339.
- ^ Chehl S, Job C, Hastings R (1985). "Transmission of leprosy in nude mice". Am J Trop Med Hyg. 34 (6): 1161–6. PMID 3914846.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ CDC Disease Info hansens_t Hansen's Disease (Leprosy)
- ^ Montestruc E, Berdonneau R (1954). "2 New cases of leprosy in infants in Martinique". Bull Soc Pathol Exot Filiales (in French). 47 (6): 781–3. PMID 14378912.
- ^ Moet FJ, Pahan D, Oskam L, Richardus JH (2008). "Effectiveness of single dose rifampicin in preventing leprosy in close contacts of patients with newly diagnosed leprosy: cluster randomised controlled trial". BMJ. 336 (7647): 761. doi:10.1136/bmj.39500.885752.BE. PMC 2287265. PMID 18332051.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ Bakker MI, Hatta M, Kwenang A; et al. (1 April 2005). "Prevention of leprosy using rifampicin as chemoprophylaxis". Am J Trop Med Hyg. 72 (4): 443–8. PMID 15827283.
{{cite journal}}
: Explicit use of et al. in:|author=
(help)CS1 maint: multiple names: authors list (link) - ^ Fine PE, Smith PG (1996). "Vaccination against leprosy—the view from 1996". Lepr Rev. 67 (4): 249–52. PMID 9033195.
- ^ Karonga prevention trial group (1996). "Randomized controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi". Lancet. 348 (9019): 17–24. doi:10.1016/S0140-6736(96)02166-6. PMID 8691924.
- ^ "Chemotherapy of Leprosy". WHO Technical Report Series 847. WHO. 1994. Retrieved 2007-03-24.
- ^ "Seventh WHO Expert Committee on Leprosy". WHO Technical Report Series 874. WHO. 1998. Retrieved 2007-03-24.
- ^ Indian Annals of Medical Science
- ^ Rees RJ, Pearson JM, Waters MF (1970). "Experimental and clinical studies on rifampicin in treatment of leprosy". Br Med J. 688 (1): 89–92. doi:10.1136/bmj.1.5688.89. PMC 1699176. PMID 4903972.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ Yawalkar SJ, McDougall AC, Languillon J, Ghosh S, Hajra SK, Opromolla DV, Tonello CJ (1982). "Once-monthly rifampicin plus daily dapsone in initial treatment of lepromatous leprosy". Lancet. 8283 (1): 1199–1202. doi:10.1016/S0140-6736(82)92334-0. PMID 6122970.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ "Mortality and Burden of Disease Estimates for WHO Member States in 2002" (xls). World Health Organization. 2002.
- ^ Last Days Of A Leper Colony. CBC News. March 22, 2003.
- ^ Surgery grants for leprosy sufferers in India. Times of India. February 2, 2009.
- ^ CDC Leprosy Fact Sheet.
- ^ a b What is Leprosy?, The Leprosy Mission Canada
- ^ World Health Organization. (1985). "Epidemiology of leprosy in relation to control. Report of a WHO Study Group". World Health Organ Tech Rep Ser. 716. Geneva: World Health Organization: 1–60. ISBN 9241207167. OCLC 12095109. PMID 3925646.
- ^ "Global leprosy situation, 2006" (PDF). Weekly Epidemiological Record. 81 (32): 309–16. 2006. PMID 16903018.
{{cite journal}}
: More than one of|number=
and|issue=
specified (help); Unknown parameter|month=
ignored (help) - ^ Artscroll Tanakh, 6
- ^ Kane J, Summerbell RC, Sigler L, Krajden S, Land G (1997). Laboratory Handbook of Dermatophytes: A clinical guide and laboratory manual of dermatophytes and other filamentous fungi from skin, hair and nails. Star Publishers (Belmont, CA). ISBN 0898631572. OCLC 37116438.
{{cite book}}
: CS1 maint: multiple names: authors list (link) - ^ "The Leprosy Archives in Bergen, Norway". Retrieved 2009-05-30.
- ^ Hansen GHA (1874). "Undersøgelser Angående Spedalskhedens Årsager (Investigations concerning the etiology of leprosy)". Norsk Mag. Laegervidenskaben (in Norwegian). 4: 1–88.
- ^ Irgens L (2002). "The discovery of the leprosy bacillus". Tidsskr nor Laegeforen. 122 (7): 708–9. PMID 11998735.
- ^ Bymuseet i Bergen
- ^ a b c d e f g McLeod, Katrina C. D. and Robin D. S. Yates (1981). "Forms of Ch'in Law: An Annotated Translation of The Feng-chen shih". Harvard Journal of Asiatic Studies. 41 (1): 111–63. Pages 152–3 & footnote 147. doi:10.2307/2719003.
{{cite journal}}
: Unknown parameter|month=
ignored (help) Angela Leung's Leprosy in China: A History (New York: Columbia University Press, 2009) is the authoritative source on leprosy in China. - ^ Herbermann, Charles, ed. (1913). Catholic Encyclopedia. New York: Robert Appleton Company. .
- ^ Brody, Saul Nathaniel (1974). The Disease of the Soul: Leprosy in Medieval Literature. Ithaca: Cornell Press.
- ^ Lock et al; p. 420
- ^ a b Kearns & Nash (2008)
- ^ Aufderheide, A. C.; Rodriguez-Martin, C. & Langsjoen, O. (1998) The Cambridge Encyclopedia of Human Paleopathology. Cambridge University Press ISBN 0521552036; p. 148.
- ^ Dwivedi & Dwivedi (2007)
- ^ Kutumbian, P. (2005) Ancient Indian Medicine. Orient Longman ISBN 8125015213; pp. XXXII-XXXIII
- ^ Robbins G, Tripathy VM, Misra VN, Mohanty RK, Shinde VS, et al. (2009). Ancient Skeletal Evidence for Leprosy in India (2000 B.C.) PLoS ONE 4(5): e5669. doi:10.1371/journal.pone.0005669
- ^ a b "Skeleton shows earliest evidence of leprosy". Associated Press. 2009-05-27. Retrieved 2009-05-29.
- ^ a b "Skeleton Pushes Back Leprosy's Origins". Science Now. 2009-05-27. Retrieved 2009-05-29.
- ^ "Leprosy belonged to Ahar Chalcolithic era: Expert". The Times of India. 2009-05-29. Retrieved 2009-05-29.
- ^ "'Oldest evidence of leprosy found in India'". The Times of India. 2009-05-27. Retrieved 2009-05-29.
- ^ Leprosy — Medical History of British India, National Library of Scotland
- ^ Hansen's disease in Japan: a brief history Kikuchi I Int J Dermatol 1997:36:629-633.
- ^ Hamilton, Bernard (2000). The leper king and his heirs: Baldwin IV and the Crusader Kingdom of Jerusalem. Cambridge, UK: Cambridge University Press. ISBN 0-521-64187-X.
- ^ Cung giu Nguyên (1955). "Contemporary Vietnamese Writing". Books Abroad. 29 (1). University of Oklahoma: 19–25. Retrieved 2010-02-28.
- ^ Kaufman MH, MacLennan WJ (2001-04-01). "Robert the Bruce and Leprosy". History of Dentistry Research Newsletter. Retrieved 2010-02-28.
- ^ Bryant A (1995). Sekigahara 1600: The Final Struggle for Power (Campaign Series, 40). Osprey Publishing (UK). ISBN 1-85532-395-8. Retrieved 2010-02-28.
- ^ "?".
- ^ "?".
- ^ "?".
- ^ "?".
- ^ "?".
Further reading
- 1877: Lewis, T. R. (1877). Leprosy In India. Calcutta: Office Of The Superintendent Of Government Printing. Retrieved 2009-08-07.
{{cite book}}
: Unknown parameter|coauthors=
ignored (|author=
suggested) (help) - 1895: Ashmead, Albert S. (1895). Pre-Columbian Leprosy. Chicago: American Medical Association Press. Retrieved 2009-08-07.
{{cite book}}
: Cite has empty unknown parameter:|coauthors=
(help) - 1895: Prize Essays On Leprosy. London: The New Sydenham Society. 1895. Retrieved 2009-08-07.
{{cite book}}
: Cite has empty unknown parameter:|coauthors=
(help) - 1896: Impey, S. P. (1896). A Handbook On Leprosy. Philadelphia: P. Blakiston, Son & Co. Retrieved 2009-08-07.
{{cite book}}
: Cite has empty unknown parameter:|coauthors=
(help) - 1916: Page, Walter Hines; Page, Arthur Wilson (1916). "Fighting Leprosy In The Philippines". The World's Work: A History of Our Time. XXXI: 310–320. Retrieved 2009-08-04.
{{cite journal}}
: Cite has empty unknown parameter:|coauthors=
(help); Unknown parameter|month=
ignored (help) - 1991:William Jopling. Leprosy stigma. Lepr Rev 1991, 62, 1-12.
External links
![](http://upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/30px-Commons-logo.svg.png)