Lymphotoxin alpha

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Lymphotoxin alpha
Protein LTA PDB 1tnr.png
PDB rendering based on 1tnr.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LTA ; LT; TNFB; TNFSF1
External IDs OMIM153440 MGI104797 HomoloGene497 ChEMBL: 2059 GeneCards: LTA Gene
RNA expression pattern
PBB GE LTA 206975 at tn.png
PBB GE LTA gnf1h00007 x at tn.png
More reference expression data
Species Human Mouse
Entrez 4049 16992
Ensembl ENSG00000173503 ENSMUSG00000024402
UniProt P01374 P09225
RefSeq (mRNA) NM_000595 NM_010735
RefSeq (protein) NP_000586 NP_034865
Location (UCSC) Chr 6:
31.57 – 31.57 Mb
Chr 17:
35.2 – 35.21 Mb
PubMed search [1] [2]

Lymphotoxin-alpha (LT-alpha) or Tumor necrosis factor-beta (TNF-β) is a protein that in humans is encoded by the LTA gene.[1][2]


Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta, which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.[3]

In LTα knockout mice, all Peyer's patches and lymph nodes will fail to develop indicating LTα's importance in immunological development.[4]


Lymphotoxin alpha has been shown to interact with LTB.[5][6][7]

See also[edit]


  1. ^ Nedwin GE, Naylor SL, Sakaguchi AY, Smith D, Jarrett-Nedwin J, Pennica D, Goeddel DV, Gray PW (Sep 1985). "Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization". Nucleic Acids Research 13 (17): 6361–73. doi:10.1093/nar/13.17.6361. PMC 321958. PMID 2995927. 
  2. ^ Aggarwal BB, Eessalu TE, Hass PE (February 1986). "Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon". Nature 318 (6047): 665–7. doi:10.1038/318665a0. PMID 3001529. 
  3. ^ "Entrez Gene: LTA lymphotoxin alpha (TNF superfamily, member 1)". 
  4. ^ Akirav, Eitan; Liao, Shan; Ruddle, Nancy (2008). "Chapter 2: Lymphoid Tissues and Organs". In Paul, William. Fundamental Immunology (Book) (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 27–55. ISBN 0-7817-6519-6. 
  5. ^ Williams-Abbott L, Walter BN, Cheung TC, Goh CR, Porter AG, Ware CF (Aug 1997). "The lymphotoxin-alpha (LTalpha) subunit is essential for the assembly, but not for the receptor specificity, of the membrane-anchored LTalpha1beta2 heterotrimeric ligand". The Journal of Biological Chemistry 272 (31): 19451–6. doi:10.1074/jbc.272.31.19451. PMID 9235946. 
  6. ^ Browning JL, Sizing ID, Lawton P, Bourdon PR, Rennert PD, Majeau GR, Ambrose CM, Hession C, Miatkowski K, Griffiths DA, Ngam-ek A, Meier W, Benjamin CD, Hochman PS (Oct 1997). "Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes". Journal of Immunology 159 (7): 3288–98. PMID 9317127. 
  7. ^ Browning JL, Dougas I, Ngam-ek A, Bourdon PR, Ehrenfels BN, Miatkowski K, Zafari M, Yampaglia AM, Lawton P, Meier W (Jan 1995). "Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors". Journal of Immunology 154 (1): 33–46. PMID 7995952. 

Further reading[edit]