Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta, which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.
In LTα knockout mice, all Peyer's patches and lymph nodes will fail to develop indicating LTα's importance in immunological development.
^Aggarwal BB, Eessalu TE, Hass PE (February 1986). "Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon". Nature318 (6047): 665–7. doi:10.1038/318665a0. PMID3001529.
^Akirav, Eitan; Liao, Shan; Ruddle, Nancy (2008). "Chapter 2: Lymphoid Tissues and Organs". In Paul, William. Fundamental Immunology (Book) (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 27–55. ISBN0-7817-6519-6.
^Williams-Abbott L, Walter BN, Cheung TC, Goh CR, Porter AG, Ware CF (Aug 1997). "The lymphotoxin-alpha (LTalpha) subunit is essential for the assembly, but not for the receptor specificity, of the membrane-anchored LTalpha1beta2 heterotrimeric ligand". The Journal of Biological Chemistry272 (31): 19451–6. doi:10.1074/jbc.272.31.19451. PMID9235946.
^Browning JL, Sizing ID, Lawton P, Bourdon PR, Rennert PD, Majeau GR, Ambrose CM, Hession C, Miatkowski K, Griffiths DA, Ngam-ek A, Meier W, Benjamin CD, Hochman PS (Oct 1997). "Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes". Journal of Immunology159 (7): 3288–98. PMID9317127.
^Browning JL, Dougas I, Ngam-ek A, Bourdon PR, Ehrenfels BN, Miatkowski K, Zafari M, Yampaglia AM, Lawton P, Meier W (Jan 1995). "Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors". Journal of Immunology154 (1): 33–46. PMID7995952.