RhoD

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RHOD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2J1L
Identifiers
Aliases	RHOD, ARHD, RHOHP1, RHOM, Rho, RhoD, ras homolog family member D
External IDs	OMIM: 605781; MGI: 108446; HomoloGene: 22409; GeneCards: RHOD; OMA:RHOD - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.2 Start 67,056,847 bp End 67,072,017 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 4,475,487 bp End 4,489,460 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell right lobe of liver skin of abdomen gums left ventricle amniotic fluid oral cavity periodontal fiber right coronary artery epithelium of esophagus Top expressed in saccule otic placode lip esophagus corneal stroma jejunum duodenum yolk sac intestinal villus pyloric antrum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein kinase binding GTP binding GTPase activity Cellular component early endosome endosome membrane endosome membrane cytosol plasma membrane intracellular anatomical structure cytoplasm cell cortex cell division site intracellular membrane-bounded organelle Biological process positive regulation of cell adhesion focal adhesion assembly actin filament bundle assembly regulation of actin cytoskeleton reorganization positive regulation of cell migration lamellipodium assembly Rho protein signal transduction regulation of focal adhesion assembly protein targeting regulation of small GTPase mediated signal transduction small GTPase mediated signal transduction actin filament organization regulation of cell shape cell migration regulation of cell migration establishment or maintenance of actin cytoskeleton polarity regulation of actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29984 11854 Ensembl ENSG00000173156 ENSMUSG00000041845 UniProt O00212 P97348 RefSeq (mRNA) NM_014578 NM_001300886 NM_007485 NM_001329989 RefSeq (protein) NP_001287815 NP_055393 NP_001316918 NP_031511 Location (UCSC) Chr 11: 67.06 – 67.07 Mb Chr 19: 4.48 – 4.49 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOD.

It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.

Interactions

RhoD has been shown to interact with CNKSR1 and DIAPH2.

Further reading

• Ridley AJ (2001). "Rho proteins: linking signaling with membrane trafficking". Traffic. 2 (5): 303–10. doi:10.1034/j.1600-0854.2001.002005303.x. PMID 11350626. S2CID 37763952.
• Shimizu F, Watanabe TK, Okuno S, et al. (1997). "Isolation of a novel human cDNA (rhoHP1) homologous to rho genes". Biochim. Biophys. Acta. 1351 (1–2): 13–6. doi:10.1016/s0167-4781(97)00008-0. PMID 9116026.
• Kim HS, Choi JY, Jung AR, et al. (2000). "Assignment of the human RhoHP1 gene (ARHD) to chromosome 11q14.3 by radiation hybrid mapping". Cytogenet. Cell Genet. 89 (1–2): 53. doi:10.1159/000015562. PMID 10894936. S2CID 84584317.
• Murphy C, Saffrich R, Olivo-Marin JC, et al. (2001). "Dual function of rhoD in vesicular movement and cell motility". Eur. J. Cell Biol. 80 (6): 391–8. doi:10.1078/0171-9335-00173. PMID 11484930.
• Zanata SM, Hovatta I, Rohm B, Püschel AW (2002). "Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse". J. Neurosci. 22 (2): 471–7. doi:10.1523/JNEUROSCI.22-02-00471.2002. PMC 6758682. PMID 11784792.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gasman S, Kalaidzidis Y, Zerial M (2003). "RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase". Nat. Cell Biol. 5 (3): 195–204. doi:10.1038/ncb935. PMID 12577064. S2CID 17891748.
• Jaffe AB, Aspenström P, Hall A (2004). "Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways". Mol. Cell. Biol. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. PMC 344169. PMID 14749388.
• Flaxenburg JA, Melter M, Lapchak PH, et al. (2004). "The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase". J. Immunol. 172 (12): 7503–9. doi:10.4049/jimmunol.172.12.7503. PMID 15187129.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Birukova AA, Chatchavalvanich S, Rios A, et al. (2006). "Differential Regulation of Pulmonary Endothelial Monolayer Integrity by Varying Degrees of Cyclic Stretch". Am. J. Pathol. 168 (5): 1749–61. doi:10.2353/ajpath.2006.050431. PMC 1606576. PMID 16651639.
• Ito Y, Kanamaru A, Tada A (2007). "A novel agent, methylophiopogonanone B, promotes Rho activation and tubulin depolymerization". Mol. Cell. Biochem. 297 (1–2): 121–9. doi:10.1007/s11010-006-9336-y. PMID 17029007. S2CID 33688226.
• Tan W, Martin D, Gutkind JS (2007). "The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4". J. Biol. Chem. 281 (51): 39542–9. doi:10.1074/jbc.M609062200. PMID 17056591.
• Lakshman N, Kim A, Bayless KJ, et al. (2007). "Rho plays a central role in regulating local cell-matrix mechanical interactions in 3D culture". Cell Motil. Cytoskeleton. 64 (6): 434–45. doi:10.1002/cm.20194. PMID 17342762.