A 20% solution of ALA is applied to the lesions, and after a 1-4 hour wait (depending on body location) to allow proper penetration of the skin, the treatment area is irradiated with blue light for 15 minutes. This generates reactive oxygen species in the skin that can lead to cell death. The treated areas are sensitive to light, and patients must protect themselves against bright sunshine for up to 48 hours after treatment. Patients must stop using topical acne medicine and avoid steam rooms, hot showers, and generally protect the skin for up to one week after treatment.
On October 2008 Dusa Pharmaceuticals announced that it was no longer developing Levulan for the treatment of acne after the phase II results failed to show statistically significant results.
- Prescription information
- Homepage of Dusapharma
- Henry Ford Hospital experience of 150 cases of acne and actinic keratosis
- http://findarticles.com/p/articles/mi_qa3931/is_200909/ai_n42040200/pg_11/ Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy Photochemistry and Photobiology, Sep/Oct 2009 by O'Connor, Aisling E, Gallagher, William M, Byrne, Annette T
- Dusa Pharmaceuticals abandons Levulan PDT- 27 Oct 2008 Dermatology times