From Wikipedia, the free encyclopedia
Mebeverine is a drug used to alleviate some of the symptoms of irritable bowel syndrome . It works by relaxing the muscles in and around the gut.[1]
Mebeverine (Colofac) 135 mg, U.K.
Medical use
Mebeverine is used to alleviate some of the symptoms of irritable bowel syndrome (IBS) and related conditions these conditions; specifically stomach pain and cramps, persistent diarrhea, and flatulence.[2]
Data from controlled clinical trials have not found a difference from placebo in the alleviating stomach pain in people with IBS.[3] [4]
It has not been tested in pregnant women nor in pregnant animals so pregnant women should not take it; it is expressed at low levels in breast milk, while no adverse effects have been reported in infants, breastfeeding women should not take this drug.[1]
Adverse effects
Adverse effects include hypersensitivity reactions and allergic reactions, immune system disorders, skin disorders including hives, edema and widespread rashes.[2]
Additionally, the following adverse effects have been reported: heartburn, indigestion, constipation, loss of appetite, general malaise, dizziness, insomnia, headache, and decreased pulse rate.[1]
It does not have systemic anticholinergic side effects.[2]
Mechanism of action
Mebeverine is an anticholinergic but its mechanism of action is not known; it appears to work directly on smooth muscle within the gastrointestinal tract and may have an anesthetic effect, may affect calcium channels , and may affect muscarinic receptors.[2]
It is metabolized mostly by esterases , and almost completely. The metabolites are excreted in urine.[2]
History
It is a second generation papaverine analog, and was first synthesized around the same time as verapamil .[5]
It was first registered in 1965.[6]
Availability
Mebeverine is a generic drug and is available internationally under many brand names.[7]
References
^ a b c "Colofac data sheet" (PDF) . New Zealand Medicines and Medical Devices Safety Authority. 14 June 2017. Retrieved 21 July 2017 .^ a b c d e "Colofac Tablets 135mg - Summary of Product Characteristics (SPC)" . UK Electronic Medicines Compendium. 26 August 2016. Retrieved 21 July 2017 .^ Annaházi, A; Róka, R; Rosztóczy, A; Wittmann, T (28 May 2014). "Role of antispasmodics in the treatment of irritable bowel syndrome" . World journal of gastroenterology . 20 (20): 6031–43. doi :10.3748/wjg.v20.i20.6031 . PMC 4033443 PMID 24876726 . {{cite journal }}: CS1 maint: unflagged free DOI (link )^ Darvish-Damavandi, M; Nikfar, S; Abdollahi, M (7 February 2010). "A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome" . World journal of gastroenterology . 16 (5): 547–53. PMC 2816265 PMID 20128021 . ^ Sneader, Walter (2005). Drug Discovery: A History ISBN 9780471899792 ^ Mebeverine page at druginfosys Page accessed Feb 1, 2015^ International page at drugs.com for Mebeverine Page accessed Feb 1, 2015
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