RAMP2

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Receptor (G protein-coupled) activity modifying protein 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol RAMP2
External IDs OMIM605154 MGI1859650 HomoloGene4274 IUPHAR: RAMP2 ChEMBL: 3315 GeneCards: RAMP2 Gene
Orthologs
Species Human Mouse
Entrez 10266 54409
Ensembl ENSG00000131477 ENSMUSG00000001240
UniProt O60895 Q9WUP0
RefSeq (mRNA) NM_005854 NM_019444
RefSeq (protein) NP_005845 NP_062317
Location (UCSC) Chr 17:
40.91 – 40.92 Mb
Chr 11:
101.25 – 101.26 Mb
PubMed search [1] [2]

Receptor activity modifying protein 2, also known as RAMP2, is a protein which in humans is encoded by the RAMP2 gene.[1][2]

Function[edit]

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N-terminus and a cytoplasmic C-terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.[1]

References[edit]

  1. ^ a b "Entrez Gene: RAMP2". 
  2. ^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature 393 (6683): 333–9. doi:10.1038/30666. PMID 9620797. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.