Ciliary neurotrophic factor receptor

From Wikipedia, the free encyclopedia
Jump to: navigation, search
ciliary neurotrophic factor receptor
Identifiers
Symbol CNTFR
Entrez 1271
HUGO 2170
OMIM 118946
RefSeq NM_001842
UniProt P26992
Other data
Locus Chr. 9 p13

The ciliary neurotrophic factor receptor also known as CNTFR binds the ciliary neurotrophic factor. This receptor and its cognate ligand support the survival of neurons.[1] This receptor is most closely related to the interleukin-6 receptor. This receptor possesses an unusual attachment to the cell membrane through a glycophosphatidylinositol linkage.[2]

Model organisms[edit]

Model organisms have been used in the study of CNTFR function. A conditional knockout mouse line, called Cntfrtm1a(EUCOMM)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty five tests were carried out on mutant mice and one significant abnormality was observed: no homozygous mutant animals were observed at weaning. The remaining tests were therefore carried out on adult heterozygous mutant animals, but no further abnormalities were seen. [5]

References[edit]

  1. ^ Davis S, Aldrich TH, Valenzuela DM, Wong VV, Furth ME, Squinto SP, Yancopoulos GD (1991). "The receptor for ciliary neurotrophic factor". Science 253 (5015): 59–63. doi:10.1126/science.1648265. PMID 1648265. 
  2. ^ Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD, Wiegand SJ (2000). "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharm Acta Helv 74 (2–3): 265–72. doi:10.1016/S0031-6865(99)00050-3. PMID 10812968. 
  3. ^ "Salmonella infection data for Cntfr". Wellcome Trust Sanger Institute. 
  4. ^ "Citrobacter infection data for Cntfr". Wellcome Trust Sanger Institute. 
  5. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. 
  6. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  7. ^ "International Knockout Mouse Consortium". 
  8. ^ "Mouse Genome Informatics". 
  9. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  10. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  11. ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  12. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 

External links[edit]