SCHEMBL5334361

SCHEMBL5334361
Identifiers
	IUPAC name 7-[(3-methoxyphenoxy)methyl]-2,3,4,5-tetrahydro-1H-3-benzazepine;
CAS Number	959867-47-1 ;
PubChem CID	59027940;
Chemical and physical data
Formula	C18H21NO2
Molar mass	283.371 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=CC(=CC=C1)OCC2=CC3=C(CCNCC3)C=C2;
	InChI InChI=1S/C18H21NO2/c1-20-17-3-2-4-18(12-17)21-13-14-5-6-15-7-9-19-10-8-16(15)11-14/h2-6,11-12,19H,7-10,13H2,1H3; Key:BFCIUKMUJQOSDE-UHFFFAOYSA-N;

SCHEMBL5334361 is a drug which acts as an agonist at the 5-HT₂ family of serotonin receptors, and was developed for the treatment of glaucoma. It is a benzazepine derivative structurally related to the anorectic drug lorcaserin. It is selective for 5-HT_2A, with an EC₅₀ of 0.4nM at 5-HT_2A vs 3.9nM at 5-HT_2C and a much lower affinity of 417nM at 5-HT_2B.^[1]

References

^ WO 2007149728, Mohapatra S, Hellberg MR, Feng Z, "Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma", assigned to Alcon Manufacturing, Ltd.

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[1] WO 2007149728, Mohapatra S, Hellberg MR, Feng Z, "Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma", assigned to Alcon Manufacturing, Ltd.

[1]

See also

References