5-HT1F receptor

From Wikipedia, the free encyclopedia
Jump to: navigation, search
5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
Identifiers
Symbols HTR1F ; 5-HT-1F; 5-HT1F; 5HT6; HTR1EL; MR77
External IDs OMIM182134 MGI99842 HomoloGene37361 IUPHAR: 5-HT1F ChEMBL: 1805 GeneCards: HTR1F Gene
RNA expression pattern
PBB GE HTR1F 221458 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3355 15557
Ensembl ENSG00000179097 ENSMUSG00000050783
UniProt P30939 Q02284
RefSeq (mRNA) NM_000866 NM_008310
RefSeq (protein) NP_000857 NP_032336
Location (UCSC) Chr 3:
88.04 – 88.04 Mb
Chr 16:
64.92 – 65.11 Mb
PubMed search [1] [2]

5-hydroxytryptamine (serotonin) receptor 1F, also known as HTR1F is a 5-HT1 receptor protein and also denotes the human gene encoding it.[1][2][3][4][5]

Agonists[edit]

  • 5-n-Butyryloxy-DMT:[6] >60-fold selectivity versus 5-HT1E receptor
  • BRL-54443 - mixed 5-HT1E/1F agonist
  • Eletriptan - mixed 5-HT1B/1D/1E/1F/2B/7 agonist
  • LY-334,370[7] - as well as related benzamides[8]
  • LY-344,864 (N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide)
  • Naratriptan - mixed 5-HT1B/1D/1F agonist

Antagonists[edit]

MLS000756415[9]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F". 
  2. ^ Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (January 1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 408–12. doi:10.1073/pnas.90.2.408. PMC 45671. PMID 8380639. 
  3. ^ Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (March 1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2184–8. doi:10.1073/pnas.90.6.2184. PMC 46050. PMID 8384716. 
  4. ^ Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM (1997). "Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)". Mol. Membr. Biol. 14 (3): 133–5. doi:10.3109/09687689709048173. PMID 9394293. 
  5. ^ Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (June 1998). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". Am. J. Med. Genet. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173. 
  6. ^ Klein MT, Dukat M, Glennon RA, Teitler M (June 2011). "Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships". J. Pharmacol. Exp. Ther. 337 (3): 860–7. doi:10.1124/jpet.111.179606. PMC 3101003. PMID 21422162. 
  7. ^ Wainscott DB, Krushinski JH, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL (2005). "[3H]-LY-334,370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties". Naunyn Schmiedebergs Arch. Pharmacol. 371 (3): 169–77. doi:10.1007/s00210-005-1035-9. PMID 15900510. 
  8. ^ Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC (2004). "Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists". Bioorg. Med. Chem. Lett. 14 (24): 6011–6. doi:10.1016/j.bmcl.2004.09.079. PMID 15546719. 
  9. ^ PudChem: MLS000756415

External links[edit]

  • "5-HT1F". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.