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E 6801.svg
IUPAC name
Molar mass 423.94 g mol−1
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

E-6801 is a partial agonist of the 5-HT6 receptor.[1] It enhanced recognition memory and reversed the memory deficits of scopolamine in an object recognition task in a rat model.[2] The mechanism of memory enhancement is due to a combined modulation of cholinergic and glutamatergic neurotransmission.

See also[edit]


  1. ^ Romero, G. (August 2006). "Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways". British Journal of Pharmacology 148 (8): 1133–43. doi:10.1038/sj.bjp.0706827. PMC 1752021. PMID 16865095. Retrieved 24 December 2011. 
  2. ^ Kendall, I. (February 2011). "E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat.". Psychopharmacology 213 (2-3): 413–30. doi:10.1007/s00213-010-1854-3. PMID 20405281.