Octatropine methylbromide: Difference between revisions
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| image = Octatropine methylbromide.svg |
| image = Octatropine methylbromide.svg |
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| CAS_number = 80-50-2 |
| CAS_number = 80-50-2 |
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| PubChem = 6647 |
| PubChem = 6647 |
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Revision as of 09:50, 31 July 2009
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| Clinical data | |
|---|---|
| Other names | 8-Methyltropinium bromide 2- propylvalerate |
| Routes of administration | Oral |
| ATC code |
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| Pharmacokinetic data | |
| Bioavailability | 10 to 25% (oral) |
| Protein binding | Unknown |
| Metabolism | Hepatic |
| Elimination half-life | Unknown |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.001.169 |
| Chemical and physical data | |
| Formula | C17H32NO2+ · Br− |
| Molar mass | 362.345 g/mol |
Octatropine methylbromide (INN) or anisotropine methylbromide (USAN), trade names Valpin, Endovalpin, Lytispasm and others,[1] is a muscarinic antagonist and antispasmodic. It was introduced to the U.S. market in 1963 as an adjunct in the treatment of peptic ulcer,[2] and promoted as being more specific to the gastrointestinal tract than other anticholinergics, although its selectivity was questioned in later studies.[3][4]
Octatropine has been superseded by more effective agents in the treatment of peptic ulcer disease, and is no longer used. It is still sold in some countries in combination with other drugs, such as phenobarbital and metamizole.
References
- ^ David J. Triggle (1997). Dictionary of Pharmacological Agents. Vol. 2. Boca Raton: Chapman & Hall/CRC. pp. p. 1467. ISBN 0-412-46630-9.
{{cite book}}:|pages=has extra text (help); Unknown parameter|coauthors=ignored (|author=suggested) (help) Retrieved on August 31, 2008 through Google Book Search. - ^ Batterman RC, Mouratoff GJ, Kaufman JE (1963). "Anisotropine methylbromide: a new antispasmodic for gastrointestinal disorders". Curr Ther Res Clin Exp. 5: 213–8. PMID 13966843.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Gyermek, Laszlo (1998). Pharmacology of antimuscarinic agents. Boca Raton: CRC Press. pp. p. 183. ISBN 0-8493-8559-8.
{{cite book}}:|pages=has extra text (help) Retrieved on August 31, 2008 through Google Book Search. - ^ Bachrach WH (1972). "Clinical evaluation of anisotropine methyl bromide (valpin), an anticholinergic drug". Am J Dig Dis. 17 (6): 505–12. doi:10.1007/BF02231205. PMID 4555460.
{{cite journal}}: Unknown parameter|month=ignored (help)
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