Armodafinil: Difference between revisions
Persephone12 (talk | contribs) created sections for indications, side effects and dosage |
Persephone12 (talk | contribs) m →Dosage |
||
| Line 47: | Line 47: | ||
==Dosage== |
==Dosage== |
||
For narcolepsy and obstructive sleep apnea, armodafinil is taken as a once daily 150mg or 250mg dose in the morning. For shift work sleep disorder, 150mg of armodafinil are taken one hour prior to starting work |
For narcolepsy and obstructive sleep apnea, armodafinil is taken as a once daily 150mg or 250mg dose in the morning. For shift work sleep disorder, 150mg of armodafinil are taken one hour prior to starting work.<ref name="urlNuvigil (Armodafinil) Drug Information: Uses, Side Effects, Drug Interactions and Warnings at RxList" /> |
||
==Side Effects== |
==Side Effects== |
||
Revision as of 13:25, 21 July 2010
 | |
| Clinical data | |
|---|---|
| Pregnancy category |
|
| Routes of administration | Oral |
| ATC code | |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Metabolism | Hepatic, including CYP3A4 and other pathways |
| Elimination half-life | 12-15 hrs |
| Excretion | Urine (as metabolites) |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.207.833 |
| Chemical and physical data | |
| Formula | C15H15NO2S |
| Molar mass | 273.351 g·mol−1 |
| 3D model (JSmol) | |
| |
Armodafinil (Nuvigil) is a stimulant-like drug produced by the pharmaceutical company Cephalon Inc., which was approved by the FDA on June 15, 2007.[1] Armodafinil is the active (−)-(R)-enantiomer of the racemic drug modafinil (Provigil).
Indications
Armodafinil is approved by the FDA for the treatment of narcolepsy and shift work sleep disorder, and as an adjunctive treatment for obstructive sleep apnea.[2]
Cephalon plans to conduct clinical trials evaluating the use of Nuvigil as a treatment for serious medical conditions such as bipolar depression, cognition abnormalities associated with schizophrenia, and fatigue in conditions such as Parkinson's disease and cancer.[3]
On January 6th, 2010, the drug was being considered for the first FDA-approved medicinally-specific drug for combating jet-lag.[4] On March 30, 2010, the FDA declined to approve use of Nuvigil to treat jet lag.[5]
Dosage
For narcolepsy and obstructive sleep apnea, armodafinil is taken as a once daily 150mg or 250mg dose in the morning. For shift work sleep disorder, 150mg of armodafinil are taken one hour prior to starting work.[2]
Side Effects
Armodafinil's common side effects include headache, nausea, insomnia and dizziness.[2]
See also
References
- ^ "CDER Drug and Biologic Approvals for Calendar Year 2007". Retrieved 2008-01-21.
- ^ a b c "Nuvigil (Armodafinil) Drug Information: Uses, Side Effects, Drug Interactions and Warnings at RxList".
- ^ "Cephalon - Pipeline,". Retrieved 2008-01-21.
- ^ A Drug’s Second Act: Battling Jet Lag Retrieved 2010-3-30.
- ^ Regulators Reject a Drug Maker’s Plan to Use Its Alertness Pill to Overcome Jet Lag Retrieved 2010-3-30.
External links
 | This psychoactive drug-related article is a stub. You can help Wikipedia by expanding it. |