Clenbuterol: Difference between revisions
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==Legal status== |
==Legal status== |
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Clenbuterol is not an ingredient of any therapeutic drug approved by the U.S. [[Food and Drug Administration]]<ref name="a"/> and is now banned for [[IOC]]-tested athletes.<ref>{{cite news |first=Katy |last=Guest |title=Clenbuterol: The new weight-loss wonder drug gripping Planet Zero |url=http://news.independent.co.uk/uk/health_medical/article2375069.ece |work=The Independent |date=2007-04-10 |accessdate=2007-04-10 | location=London}}</ref> See further at [[List of doping cases in sport]]. [[Poland|Polish]] |
Clenbuterol is not an ingredient of any therapeutic drug approved by the U.S. [[Food and Drug Administration]]<ref name="a"/> and is now banned for [[IOC]]-tested athletes.<ref>{{cite news |first=Katy |last=Guest |title=Clenbuterol: The new weight-loss wonder drug gripping Planet Zero |url=http://news.independent.co.uk/uk/health_medical/article2375069.ece |work=The Independent |date=2007-04-10 |accessdate=2007-04-10 | location=London}}</ref> See further at [[List of doping cases in sport]]. [[Poland|Polish]] |
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==References== |
==References== |
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Revision as of 08:01, 15 February 2011
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| Clinical data | |
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| Pregnancy category |
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| Routes of administration | oral |
| ATC code | |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | 89-98% orally |
| Metabolism | ? |
| Elimination half-life | 36-39 hours |
| Excretion | ? |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.048.499 |
| Chemical and physical data | |
| Formula | C12H18Cl2N2O |
| Molar mass | 277.19 g·mol−1 |
| 3D model (JSmol) | |
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Clenbuterol (Spiropent, Ventipulmin) is a sympathomimetic amine used by sufferers of breathing disorders as a decongestant and bronchodilator. People with chronic breathing disorders such as asthma use this as a bronchodilator to make breathing easier. It is most commonly available as the hydrochloride salt clenbuterol hydrochloride.
Effects and dosage
Clenbuterol is a β2 agonist with some structural and pharmacological similarities to epinephrine and salbutamol, but its effects are more potent and longer-lasting as a stimulant and thermogenic drug. It causes an increase in aerobic capacity, central nervous system stimulation, and an increase in blood pressure and oxygen transportation. It increases the rate at which body fat is metabolized, simultaneously increasing the body's BMR. It is commonly used for smooth muscle relaxant properties. This means that it is a bronchodilator and tocolytic. It is usually used in dosages anywhere from 20-60 micrograms a day when prescribed. A dose of about 120 μg should never be exceeded in a day [citation needed]. It is also prescribed for treatment of horses; however, equestrian usage is usually the liquid form of clenbuterol. Clenbuterol is also a sympathomimetic in the peripheral nervous system.
Human use
Clenbuterol is approved for use in some countries (via prescription only) as a bronchodilator for asthma patients.[1] Recently though, the drug has been publicized for its off-label use as a weight loss drug, similar to usage of other sympathomimetic amines such as ephedrine. It is commonly used as a slimming aid despite lack of sufficient clinical evidence supporting such use.
Clenbuterol has also been used as a performance-enhancing drug. In 2010, a number of athletes were banned after using the drug, including Polish canoeist Adam Seroczynski, British hurdler Callum Priestley and Chinese Olympic judo champion Tong Wen. Three cyclists were also accused of taking the drug. Three-time Tour de France champion Alberto Contador of Spain tested positive for the drug at the 2010 Tour de France. The news came out during the UCI Road Cycling World Championships held in Geelong, Australia.[2] In May, the UCI suspended Italian cyclist Alessandro Colo and Chinese rider, Li Fuyu, a member of Team RadioShack, was suspended after testing positive for the drug during a Belgian race.
American swimmer Jessica Hardy tested positive at the U.S. trials in July 2008. She served a one-year suspension, having claimed that she unknowingly took the drug in a contaminated food supplement. Former New York Mets clubhouse employee Kirk Radomski admitted to distributing clenbuterol to dozens of current and former Major League Baseball players and associates in his plea deal.[3]
In September 2010, St. Louis Cardinals minor league shortstop Lainer Bueno received a 50-game suspension for the 2011 season as a result of testing positive for clenbuterol.[4]
Contraindications and cautions
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- Hypersensitivity to the medicine
- Thyrotoxicosis
- Tachycardia
- Subaortic stenosis
- Acute myocardial infarction
- Hypertension
- Pregnancy
Overdosage
Excessive[clarification needed] usage can cause muscle tremor, headache, dizziness and gastric irritation. Persons self-administering the drug for weight loss or to improve athletic performance have experienced nausea, vomiting, diaphoresis, palpitations, tachycardia and myocardial infarction. Abuse of the drug may be confirmed by detecting its presence in serum or urine.[5]
Veterinary use
The European Union prohibits the use of Clenbuterol in food-producing animals. Clenbuterol is used in other parts of the world for the treatment of allergic respiratory disease in horses, as it is a bronchodilator. A common trade name is Ventipulmin. It can be used both orally and intravenously. It is also used in cattle to relax the uterus in cattle, usually at the time of parturition.[6] It is also a non-steroidal anabolic and metabolism accelerator, through a mechanism not well understood. Its ability to increase the muscle-to-fat body ratio makes its illegal use in livestock popular to obtain leaner meats.
Food contamination
In September 2006 over 330 people in Shanghai were reported to have been poisoned by eating pork contaminated by clenbuterol that had been fed to the animals to keep their meat lean. There are also other informal reports on localized food contamination cases by clenbuterol in the U.S., which led to setting rules that limit consumption of this medicine only to horses.[7]
In February 2009, at least 70 people in one Chinese province (Guangdong) suffered food poisoning after eating pig organs believed to contain clenbuterol residue. The victims complained of stomachaches and diarrhea after eating pig organs bought in local markets.[8][9]
In the 2010 Tour de France, Alberto Contador tested positive for clenbuterol. He claims it was due to food contamination, citing the 50 picogram (5 × 10−11 g) per millilitre concentration of the drug in his sample. He has been handed a one-year suspension from competition by the Spanish Cycling Federation (RFEC). On February 14, 2011 Alberto Contador was cleared of doping, and the Spanish cycling federation canceled its Jan. 26 proposal for a one-year ban.
Legal status
Clenbuterol is not an ingredient of any therapeutic drug approved by the U.S. Food and Drug Administration[1] and is now banned for IOC-tested athletes.[10] See further at List of doping cases in sport. Polish
References
- ^ a b "Clenbuterol", Daily Mail, 2009-10-01, retrieved 2010-04-07
- ^ http://www.google.com/hostednews/ap/article/ALeqM5i3PPjohFh-pxv8X9LPQ4C50npndwD9IHVSIG0?docId=D9IHVSIG0
- ^ http://www.huffingtonpost.com/2010/09/30/alberto-contador-tests-po_n_744711.html
- ^ "Three Minor League players suspended". MLB.com. September 30, 2010.
- ^ R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 8th edition, Biomedical Publications, Foster City, CA, 2008, pp. 325-326.
- ^ http://www.noahcompendium.co.uk/Boehringer_Ingelheim_Limited/Planipart_Solution_for_Injection_30_micrograms_ml/-37725.html
- ^ "Pigs fed on bodybuilder steroids cause food poisoning in Shanghai". AFP. 2006-09-19. Retrieved 2006-09-19.
{{cite news}}: Cite has empty unknown parameter:|1=(help) - ^ "China: 70 ill from tainted pig organs - CNN.com". CNN. 2009-02-23. Retrieved 2010-04-30.
- ^ http://www.chinadaily.com.cn/china/2009-02/23/content_7501017.htm
- ^ Guest, Katy (2007-04-10). "Clenbuterol: The new weight-loss wonder drug gripping Planet Zero". The Independent. London. Retrieved 2007-04-10.
External links
- Charles F. Kearns, Kenneth H. McKeever, Karyn Malinowski, Maggie B. Struck, and Takashi Abe (2001). "Chronic administration of therapeutic levels of clenbuterol acts as a repartitioning agent". J Appl Physiol. 91 (5): 2064–2070. PMID 11641345.
{{cite journal}}: CS1 maint: multiple names: authors list (link)