Epigen

EPGN
Identifiers
Aliases	EPGN, ALGV3072, EPG, PRO9904, epithelial mitogen
External IDs	MGI: 1919170; HomoloGene: 19527; GeneCards: EPGN; OMA:EPGN - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	74,316,789 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	91,183,074 bp
RNA expression pattern
	Top expressed in
	mucosa of esophagus; ; vagina; ; skin of leg; ; appendix; ; skin of abdomen; ; right lung; ; tonsil; ; bone marrow cells; ; ectocervix; ; mucosa of transverse colon;
	Top expressed in
	embryo; ; cornea; ; embryo; ; hair follicle; ; spermatid; ; lip; ; skin of abdomen; ; conjunctival fornix; ; skin of back; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	epidermal growth factor receptor binding; growth factor activity;
Cellular component	integral component of membrane; extracellular region; integral component of plasma membrane; intracellular anatomical structure; membrane; extracellular space; clathrin-coated vesicle membrane;
Biological process	positive regulation of epidermal growth factor-activated receptor activity; positive regulation of mitotic nuclear division; positive regulation of MAP kinase activity; angiogenesis; positive regulation of cell population proliferation; MAPK cascade; positive regulation of epithelial cell proliferation; epidermal growth factor receptor signaling pathway; signal transduction; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	255324
	71920
	ENSG00000182585
	ENSMUSG00000035020
	Q6UW88
	Q924X1
NM_001013442; NM_001270989; NM_001270990; NM_001270991; NM_001270992;
	NM_001270993
	NM_053087
	NP_001257918; NP_001257919; NP_001257920; NP_001257921; NP_001257922
	NP_444317
	Wikidata
View/Edit Human	View/Edit Mouse

Epigen also known as epithelial mitogen is a protein that in humans is encoded by the EPGN gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182585 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035020 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Epithelial mitogen".
^ Schneider MR, Yarden Y (2014). "Structure and function of epigen, the last EGFR ligand". Semin. Cell Dev. Biol. 28: 57–61. doi:10.1016/j.semcdb.2013.12.011. PMC 4037347. PMID 24374012.

External links

epigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182585 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035020 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Epithelial mitogen".

[pmid24374012-6] Schneider MR, Yarden Y (2014). "Structure and function of epigen, the last EGFR ligand". Semin. Cell Dev. Biol. 28: 57–61. doi:10.1016/j.semcdb.2013.12.011. PMC 4037347. PMID 24374012.

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