Neuregulin 2

From Wikipedia, the free encyclopedia
  (Redirected from NRG2)
Jump to navigation Jump to search
AliasesNRG2, DON1, HRG2, NTAK, neuregulin 2
External IDsOMIM: 603818 MGI: 1098246 HomoloGene: 75024 GeneCards: NRG2
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for NRG2
Genomic location for NRG2
Band5q31.2Start139,846,779 bp[1]
End140,043,299 bp[1]
RNA expression pattern
PBB GE NRG2 206879 s at fs.png

PBB GE NRG2 208062 s at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)



Location (UCSC)Chr 5: 139.85 – 140.04 MbChr 18: 36.02 – 36.2 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Neuregulin 2, also known as NRG2, is a protein which in humans is encoded by the NRG2 gene.[5][6][7]


Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described.[5]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158458 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060275 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: NRG2 neuregulin 2".
  6. ^ Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ (May 1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509–12. doi:10.1038/387509a0. PMID 9168114.
  7. ^ Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C (May 1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases". Nature. 387 (6632): 512–6. doi:10.1038/387512a0. PMID 9168115.

Further reading[edit]