Neuregulin 2

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NRG2
Identifiers
Aliases NRG2, DON1, HRG2, NTAK, neuregulin 2
External IDs MGI: 1098246 HomoloGene: 75024 GeneCards: NRG2
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for NRG2
Genomic location for NRG2
Band 5q31.2 Start 139,846,779 bp[1]
End 140,043,299 bp[1]
RNA expression pattern
PBB GE NRG2 206879 s at fs.png

PBB GE NRG2 208062 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001167891

RefSeq (protein)

NP_001171864
NP_004874
NP_053584
NP_053585
NP_053586

n/a

Location (UCSC) Chr 5: 139.85 – 140.04 Mb Chr 5: 36.02 – 36.2 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuregulin 2, also known as NRG2, is a protein which in humans is encoded by the NRG2 gene.[5][6][7]

Function[edit]

Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158458 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060275 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: NRG2 neuregulin 2". 
  6. ^ Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ (May 1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509–12. PMID 9168114. doi:10.1038/387509a0. 
  7. ^ Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C (May 1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases". Nature. 387 (6632): 512–6. PMID 9168115. doi:10.1038/387512a0. 

Further reading[edit]