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Neuregulin 2
Symbols NRG2 ; DON1; HRG2; NTAK
External IDs OMIM603818 HomoloGene75024 GeneCards: NRG2 Gene
RNA expression pattern
PBB GE NRG2 206879 s at tn.png
PBB GE NRG2 208062 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9542 100042150
Ensembl ENSG00000158458 ENSMUSG00000060275
UniProt O14511 P56974
RefSeq (mRNA) NM_001184935 NM_001167891
RefSeq (protein) NP_001171864 NP_001161363
Location (UCSC) Chr 5:
139.23 – 139.42 Mb
Chr 18:
36.02 – 36.2 Mb
PubMed search [1] [2]

Neuregulin 2, also known as NRG2, is a protein which in humans is encoded by the NRG2 gene.[1][2][3]


Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described.[1]


  1. ^ a b "Entrez Gene: NRG2 neuregulin 2". 
  2. ^ Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ (May 1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature 387 (6632): 509–12. doi:10.1038/387509a0. PMID 9168114. 
  3. ^ Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C (May 1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases". Nature 387 (6632): 512–6. doi:10.1038/387512a0. PMID 9168115. 

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