FGF17

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FGF17
Identifiers
AliasesFGF17, FGF-13, HH20, FGF-17, fibroblast growth factor 17
External IDsMGI: 1202401 HomoloGene: 2872 GeneCards: FGF17
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for FGF17
Genomic location for FGF17
Band8p21.3Start22,042,398 bp[1]
End22,048,809 bp[1]
RNA expression pattern
PBB GE FGF17 221376 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001304478
NM_003867

NM_008004
NM_001360108

RefSeq (protein)

NP_001291407
NP_003858

NP_032030
NP_001347037

Location (UCSC)Chr 8: 22.04 – 22.05 MbChr 14: 70.64 – 70.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fibroblast growth factor 17 is a protein that in humans is encoded by the FGF17 gene.[5][6][7]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was shown to be prominently expressed in the cerebellum and cortex. The mouse homolog of this gene was localized to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, which suggests a role in central nervous system, bone and vascular development. This gene was referred to as FGF-13 in reference 2, however, its amino acid sequence and chromosomal localization are identical to FGF17.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158815 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022101 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Hoshikawa M, Ohbayashi N, Yonamine A, Konishi M, Ozaki K, Fukui S, Itoh N (Apr 1998). "Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain". Biochem Biophys Res Commun. 244 (1): 187–91. doi:10.1006/bbrc.1998.8239. PMID 9514906.
  6. ^ Greene JM, Li YL, Yourey PA, Gruber J, Carter KC, Shell BK, Dillon PA, Florence C, Duan DR, Blunt A, Ornitz DM, Ruben SM, Alderson RF (Oct 1998). "Identification and characterization of a novel member of the fibroblast growth factor family". Eur J Neurosci. 10 (5): 1911–25. doi:10.1046/j.1460-9568.1998.00211.x. PMID 9751161.
  7. ^ a b "Entrez Gene: FGF17 fibroblast growth factor 17".

Further reading[edit]