GFRA1

GFRA1
Identifiers
Aliases	GFRA1, GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1, GDNF family receptor alpha 1
External IDs	OMIM: 601496; MGI: 1100842; HomoloGene: 3855; GeneCards: GFRA1; OMA:GFRA1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q25.3 Start 116,056,925 bp End 116,273,467 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 D2|19 54.18 cM Start 58,224,036 bp End 58,444,341 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trigeminal ganglion spinal ganglia pars reticulata parietal pleura corpus epididymis lactiferous duct pars compacta nipple left uterine tube cardia Top expressed in vestibular membrane of cochlear duct habenula facial motor nucleus dentate gyrus of hippocampal formation granule cell left lobe of liver lateral septal nucleus iris medullary collecting duct ciliary body substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding glial cell-derived neurotrophic factor receptor activity signaling receptor activity Cellular component anchored component of membrane extracellular exosome membrane extrinsic component of membrane intracellular anatomical structure plasma membrane external side of plasma membrane receptor complex Biological process cell surface receptor signaling pathway nervous system development MAPK cascade glial cell-derived neurotrophic factor receptor signaling pathway axon guidance regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2674 14585 Ensembl ENSG00000151892 ENSMUSG00000025089 UniProt P56159 P97785 RefSeq (mRNA) NM_001145453 NM_005264 NM_145793 NM_001348096 NM_001348098 NM_001348099 NM_001285457 NM_010279 RefSeq (protein) NP_001138925 NP_005255 NP_665736 NP_001335025 NP_001335027 NP_001335028 NP_001369485 NP_001369486 NP_001369487 NP_001369488 NP_001369489 NP_001369490 NP_001272386 NP_034409 Location (UCSC) Chr 10: 116.06 – 116.27 Mb Chr 19: 58.22 – 58.44 Mb PubMed search
Wikidata
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GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor, is a protein that in humans is encoded by the GFRA1 gene.

Function

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Interactions

GDNF family receptor alpha 1 has been shown to interact with GDNF and RET proto-oncogene.

See also

• GFRα

Further reading

• Treanor JJ, Goodman L, de Sauvage F, Stone DM, Poulsen KT, Beck CD, Gray C, Armanini MP, Pollock RA, Hefti F, Phillips HS, Goddard A, Moore MW, Buj-Bello A, Davies AM, Asai N, Takahashi M, Vandlen R, Henderson CE, Rosenthal A (Jul 1996). "Characterization of a multicomponent receptor for GDNF". Nature. 382 (6586): 80–3. doi:10.1038/382080a0. PMID 8657309.
• Jing S, Wen D, Yu Y, Holst PL, Luo Y, Fang M, Tamir R, Antonio L, Hu Z, Cupples R, Louis JC, Hu S, Altrock BW, Fox GM (Jun 1996). "GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF". Cell. 85 (7): 1113–24. doi:10.1016/S0092-8674(00)81311-2. PMID 8674117.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Gattei V, Celetti A, Cerrato A, Degan M, De Iuliis A, Rossi FM, Chiappetta G, Consales C, Improta S, Zagonel V, Aldinucci D, Agosti V, Santoro M, Vecchio G, Pinto A, Grieco M (Apr 1997). "Expression of the RET receptor tyrosine kinase and GDNFR-alpha in normal and leukemic human hematopoietic cells and stromal cells of the bone marrow microenvironment". Blood. 89 (8): 2925–37. PMID 9108413.
• Sanicola M, Hession C, Worley D, Carmillo P, Ehrenfels C, Walus L, Robinson S, Jaworski G, Wei H, Tizard R, Whitty A, Pepinsky RB, Cate RL (Jun 1997). "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins". Proceedings of the National Academy of Sciences of the United States of America. 94 (12): 6238–43. doi:10.1073/pnas.94.12.6238. PMC 21033. PMID 9177201.
• Baloh RH, Tansey MG, Golden JP, Creedon DJ, Heuckeroth RO, Keck CL, Zimonjic DB, Popescu NC, Johnson EM, Milbrandt J (May 1997). "TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret". Neuron. 18 (5): 793–802. doi:10.1016/S0896-6273(00)80318-9. PMID 9182803.
• Klein RD, Sherman D, Ho WH, Stone D, Bennett GL, Moffat B, Vandlen R, Simmons L, Gu Q, Hongo JA, Devaux B, Poulsen K, Armanini M, Nozaki C, Asai N, Goddard A, Phillips H, Henderson CE, Takahashi M, Rosenthal A (Jun 1997). "A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor". Nature. 387 (6634): 717–21. doi:10.1038/42722. PMID 9192898.
• Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM (Dec 1997). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". The Journal of Biological Chemistry. 272 (52): 33111–7. doi:10.1074/jbc.272.52.33111. PMID 9407096.
• Eng C, Myers SM, Kogon MD, Sanicola M, Hession C, Cate RL, Mulligan LM (Feb 1998). "Genomic structure and chromosomal localization of the human GDNFR-alpha gene". Oncogene. 16 (5): 597–601. doi:10.1038/sj.onc.1201573. PMID 9482105.
• Shefelbine SE, Khorana S, Schultz PN, Huang E, Thobe N, Hu ZJ, Fox GM, Jing S, Cote GJ, Gagel RF (Apr 1998). "Mutational analysis of the GDNF/RET-GDNFR alpha signaling complex in a kindred with vesicoureteral reflux". Human Genetics. 102 (4): 474–8. doi:10.1007/s004390050724. PMID 9600247.
• Cacalano G, Fariñas I, Wang LC, Hagler K, Forgie A, Moore M, Armanini M, Phillips H, Ryan AM, Reichardt LF, Hynes M, Davies A, Rosenthal A (Jul 1998). "GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney". Neuron. 21 (1): 53–62. doi:10.1016/S0896-6273(00)80514-0. PMC 2710137. PMID 9697851.
• Enokido Y, de Sauvage F, Hongo JA, Ninkina N, Rosenthal A, Buchman VL, Davies AM (Sep 1998). "GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin". Current Biology. 8 (18): 1019–22. doi:10.1016/S0960-9822(07)00422-8. PMID 9740802.
• Tansey MG, Baloh RH, Milbrandt J, Johnson EM (Mar 2000). "GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival". Neuron. 25 (3): 611–23. doi:10.1016/S0896-6273(00)81064-8. PMID 10774729.
• Hase A, Suzuki H, Arahata K, Akazawa C (Jul 1999). "Expression of human GFR alpha-1 (GDNF receptor) at the neuromuscular junction and myelinated nerves". Neuroscience Letters. 269 (1): 55–7. doi:10.1016/S0304-3940(99)00419-X. hdl:10271/1630. PMID 10821644.
• Cik M, Masure S, Lesage AS, Van Der Linden I, Van Gompel P, Pangalos MN, Gordon RD, Leysen JE (Sep 2000). "Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions". The Journal of Biological Chemistry. 275 (36): 27505–12. doi:10.1074/jbc.M000306200. PMID 10829012.
• Paratcha G, Ledda F, Baars L, Coulpier M, Besset V, Anders J, Scott R, Ibáñez CF (Jan 2001). "Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts". Neuron. 29 (1): 171–84. doi:10.1016/S0896-6273(01)00188-X. PMID 11182089.
• Gimm O, Dziema H, Brown J, Hoang-Vu C, Hinze R, Dralle H, Mulligan LM, Eng C (Apr 2001). "Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma". Oncogene. 20 (17): 2161–70. doi:10.1038/sj.onc.1204289. PMID 11360200.
• Japón MA, Urbano AG, Sáez C, Segura DI, Cerro AL, Diéguez C, Alvarez CV (Apr 2002). "Glial-derived neurotropic factor and RET gene expression in normal human anterior pituitary cell types and in pituitary tumors". The Journal of Clinical Endocrinology and Metabolism. 87 (4): 1879–84. doi:10.1210/jc.87.4.1879. PMID 11932334.

External links

• Overview of all the structural information available in the PDB for UniProt: P56159 (GDNF family receptor alpha-1) at the PDBe-KB.