Darodipine

Darodipine
Names
	IUPAC name 4-(2,1,3-Benzoxadiazol-7-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
Identifiers
CAS Number	72803-02-2;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL2104154;
ChemSpider	46790;
PubChem CID	51701;
UNII	N4AL7X96GL ;
CompTox Dashboard (EPA)	DTXSID90223125 ;
	InChI InChI=1/C19H21N3O5/c1-5-25-18(23)14-10(3)20-11(4)15(19(24)26-6-2)16(14)12-8-7-9-13-17(12)22-27-21-13/h7-9,16,20H,5-6H2,1-4H3 Key: QERUYFVNIOLCHV-UHFFFAOYAW;
	SMILES O=C(OCC)\C3=C(\N\C(=C(\C(=O)OCC)C3c1cccc2nonc12)C)C;
Properties
Chemical formula	C19H21N3O5
Molar mass	371.393 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Darodipine is an experimental calcium channel blocker that based on animal models may reduce neuronal cytoskeletal alterations during aging and in neurodegenerative disorders. Studies performed on rats have shown darodipine to have an effect on brain serotonergic systems. Darodipine increased the 5-HIAA/5-HT ratio within various parts of the brain.^[1] Darodipine has also been shown to impair memory and learning processes on mice.^[2]

References

^ Gaggi, Renato (June–July 1995). "Effects of isradipine and darodipine on serotonergic system of the rat brain". Pharmacology, Biochemistry and Behavior. 51 (2): 183–187.
^ Lamberti, C. (Dec 1994). "Effects of the calcium-channel blockers darodipine and nimodipine on amnesia induced by three different hypoxic methods". Pharmacological Research. 30: 359.

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[1] Gaggi, Renato (June–July 1995). "Effects of isradipine and darodipine on serotonergic system of the rat brain". Pharmacology, Biochemistry and Behavior. 51 (2): 183–187.

[2] Lamberti, C. (Dec 1994). "Effects of the calcium-channel blockers darodipine and nimodipine on amnesia induced by three different hypoxic methods". Pharmacological Research. 30: 359.

[1]

[2]

See also

References