Neurotrophin-4

NTF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HCF, 1B8M, 1B98
Identifiers
Aliases	NTF4, GLC10, GLC1O, NT-4, NT-4/5, NT-5, NT4, NT5, NTF5, neurotrophin 4
External IDs	OMIM: 162662 MGI: 97381 HomoloGene: 4503 GeneCards: NTF4
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 49,061,066 bp End 49,065,076 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B3|7 29.3 cM Start 45,063,119 bp End 45,066,603 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skeletal muscle tissue skin of abdomen prostate gastrocnemius muscle minor salivary glands right uterine tube placenta vagina right lung upper lobe of left lung Top expressed in hand molar sternocleidomastoid muscle tibialis anterior muscle upper arm knee joint triceps brachii muscle urothelium vas deferens quadriceps femoris muscle More reference expression data BioGPS n/a
Gene ontology Molecular function neurotrophin p75 receptor binding signaling receptor binding protein binding growth factor activity Cellular component cytoplasmic vesicle extracellular region extracellular space synaptic vesicle axon dendrite Biological process negative regulation of neuron apoptotic process regulation of neuron differentiation adult locomotory behavior sensory organ boundary specification cell-cell signaling neuron projection morphogenesis innervation negative regulation of cell death long-term memory taste bud development mechanoreceptor differentiation transmembrane receptor protein tyrosine kinase signaling pathway ganglion mother cell fate determination epidermis development regulation of signaling receptor activity activation of phospholipase C activity neurotrophin TRK receptor signaling pathway peripheral nervous system development memory nerve development nerve growth factor signaling pathway modulation of chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4909 78405 Ensembl ENSG00000225950 ENSMUSG00000074121 UniProt P34130 Q80VU4 RefSeq (mRNA) NM_006179 NM_001395489 NM_198190 RefSeq (protein) NP_006170 NP_937833 Location (UCSC) Chr 19: 49.06 – 49.07 Mb Chr 7: 45.06 – 45.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Neurotrophin-4 (NT-4), also known as neurotrophin-5 (NT-5), is a protein that in humans is encoded by the NTF4 gene. It is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase.

See also

• Tropomyosin receptor kinase B § Agonists

Further reading

• Childs AJ, Bayne RA, Murray AA, et al. (2010). "Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development". Dev. Dyn. 239 (4): 1211–9. doi:10.1002/dvdy.22252. PMC 3410523. PMID 20175187.
• Vithana EN, Nongpiur ME, Venkataraman D, et al. (2010). "Identification of a novel mutation in the NTF4 gene that causes primary open-angle glaucoma in a Chinese population". Mol. Vis. 16: 1640–5. PMC 2927376. PMID 20806036.
• Truzzi F, Marconi A, Lotti R, et al. (2008). "Neurotrophins and their receptors stimulate melanoma cell proliferation and migration". J. Invest. Dermatol. 128 (8): 2031–40. doi:10.1038/jid.2008.21. PMID 18305571.
• Harel S, Jin S, Fisch B, et al. (2006). "Tyrosine kinase B receptor and its activated neurotrophins in ovaries from human fetuses and adults". Mol. Hum. Reprod. 12 (6): 357–65. doi:10.1093/molehr/gal033. PMID 16648150.
• Ribasés M, Hervás A, Ramos-Quiroga JA, et al. (2008). "Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder". Biol. Psychiatry. 63 (10): 935–45. doi:10.1016/j.biopsych.2007.11.004. PMID 18179783.
• Chen ZY, Ieraci A, Teng H, et al. (2005). "Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway". J. Neurosci. 25 (26): 6156–66. doi:10.1523/JNEUROSCI.1017-05.2005. PMC 1201519. PMID 15987945.
• Pasutto F, Matsumoto T, Mardin CY, et al. (2009). "Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma". Am. J. Hum. Genet. 85 (4): 447–56. doi:10.1016/j.ajhg.2009.08.016. PMC 2756554. PMID 19765683.
• Ibáñez CF (1996). "Neurotrophin-4: the odd one out in the neurotrophin family". Neurochem. Res. 21 (7): 787–93. doi:10.1007/BF02532301. PMID 8873083.
• Nalbandian A, Pang AL, Rennert OM, et al. (2005). "A novel function of differentiation revealed by cDNA microarray profiling of p75NTR-regulated gene expression". Differentiation. 73 (8): 385–96. doi:10.1111/j.1432-0436.2005.00040.x. PMID 16316409.
• Liu Y, Liu W, Crooks K, et al. (2010). "No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma". Am. J. Hum. Genet. 86 (3): 498–9, author reply 500. doi:10.1016/j.ajhg.2009.11.018. PMC 2833375. PMID 20215012.
• Götz R, Schartl M (1994). "The conservation of neurotrophic factors during vertebrate evolution". Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 108 (1): 1–10. PMID 8061955.
• Gratacòs M, EscaramÃs G, Bustamante M, et al. (2010). "Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease". J Psychiatr Res. 44 (13): 834–40. doi:10.1016/j.jpsychires.2010.01.009. PMID 20219210.
• Chakrabarti B, Dudbridge F, Kent L, et al. (2009). "Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome". Autism Research. 2 (3): 157–77. doi:10.1002/aur.80. PMID 19598235.
• Mizuno N, Shiba H, Inui T, et al. (2008). "Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells". J. Periodontol. 79 (11): 2182–9. doi:10.1902/jop.2008.070402. PMID 18980528.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rao KN, Kaur I, Parikh RS, et al. (2010). "Variations in NTF4, VAV2, and VAV3 genes are not involved with primary open-angle and primary angle-closure glaucomas in an indian population". Invest. Ophthalmol. Vis. Sci. 51 (10): 4937–41. doi:10.1167/iovs.10-5553. PMID 20463313.
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053.
• Mercader JM; Saus E; Agüera Z; et al. (2008). "Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders". Hum. Mol. Genet. 17 (9): 1234–44. doi:10.1093/hmg/ddn013. PMID 18203754.
• Walz JC; Magalhães PV; Giglio LM; et al. (2009). "Increased serum neurotrophin-4/5 levels in bipolar disorder". J Psychiatr Res. 43 (7): 721–3. doi:10.1016/j.jpsychires.2008.10.005. PMID 19081579.
• Prakash YS, Iyanoye A, Ay B, et al. (2006). "Neurotrophin effects on intracellular Ca2+ and force in airway smooth muscle". Am. J. Physiol. Lung Cell Mol. Physiol. 291 (3): L447–56. doi:10.1152/ajplung.00501.2005. PMID 16648236.

External links

• neurotrophin+4 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• neurotrophin+5 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)