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RAMP3

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RAMP3
Identifiers
AliasesRAMP3, entrez:10268, receptor activity modifying protein 3
External IDsOMIM: 605155; MGI: 1860292; HomoloGene: 4276; GeneCards: RAMP3; OMA:RAMP3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005856

NM_019511

RefSeq (protein)

NP_005847

NP_062384

Location (UCSC)Chr 7: 45.16 – 45.19 MbChr 11: 6.61 – 6.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Receptor activity modifying protein 3, also known as RAMP3, is a human gene.[5][6]

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In humans and other mammals, there are 3 RAMPS, while in fish there are more, with sub-variants. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor with low affinity for CGRP.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122679Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041046Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: RAMP3".
  6. ^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–9. Bibcode:1998Natur.393..333M. doi:10.1038/30666. PMID 9620797. S2CID 4364526.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.