Dazopride: Difference between revisions

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Dazopride
Clinical data
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • 4-amino-5-chloro-N-(1,2-diethylpyrazolidin-4-yl)-2-methoxy-benzamide
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC15H23ClN4O2
Molar mass326.82 g/mol g·mol−1

Dazopride is an antiemetic and gastroprokinetic agent of the benzamide class which was never marketed.[1][2][3][4][5] It acts as a 5-HT3 receptor antagonist and 5-HT4 receptor agonist.[3][4][6] In addition to its gastrointestinal effects, dazopride facilitates learning and memory in mice.[7]

See also

References

  1. ^ Grant SC, Kris MG, Gralla RJ, Clark RA, Tyson LB (1993). "Dose-ranging evaluation of the substituted benzamide dazopride when used as an antiemetic in patients receiving anticancer chemotherapy". Cancer Chemotherapy and Pharmacology. 31 (6): 442–4. PMID 8453682.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Alphin RS, Proakis AG, Leonard CA; et al. (1986). "Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility". Digestive Diseases and Sciences. 31 (5): 524–9. PMID 3698769. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ a b Costall B, Domeney AM, Gunning SJ; et al. (1987). "The action of dazopride to enhance gastric emptying and block emesis". Neuropharmacology. 26 (7A): 669–77. PMID 3114664. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  4. ^ a b Costall B, Domeney AM, Naylor RJ, Tattersall FD (1987). "Emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs". Neuropharmacology. 26 (9): 1321–6. PMID 2890117. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  5. ^ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
  6. ^ Villalón CM, den Boer MO, Heiligers JP, Saxena PR (1991). "Further characterization, by use of tryptamine and benzamide derivatives, of the putative 5-HT4 receptor mediating tachycardia in the pig". British Journal of Pharmacology. 102 (1): 107–12. PMC 1917868. PMID 2043916. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  7. ^ Montgomery, S. A.; Halbreich, Uriel (2000). Pharmacotherapy for mood, anxiety, and cognitive disorders. Washington, DC: American Psychiatric Press. ISBN 0-88048-885-9.{{cite book}}: CS1 maint: multiple names: authors list (link)



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