CHRNB2

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Cholinergic receptor, nicotinic, beta 2 (neuronal)

Rendering based on PDB 2GVT.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CHRNB2 ; EFNL3; nAChRB2
External IDs OMIM118507 MGI87891 HomoloGene595 IUPHAR: β2 ChEMBL: 1883 GeneCards: CHRNB2 Gene
RNA expression pattern
PBB GE CHRNB2 206635 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1141 11444
Ensembl ENSG00000160716 ENSMUSG00000027950
UniProt P17787 Q9ERK7
RefSeq (mRNA) NM_000748 NM_009602
RefSeq (protein) NP_000739 NP_033732
Location (UCSC) Chr 1:
154.54 – 154.55 Mb
Chr 3:
89.75 – 89.76 Mb
PubMed search [1] [2]

Neuronal acetylcholine receptor subunit beta-2 is a protein that in humans is encoded by the CHRNB2 gene.[1][2]

Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.[2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article
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Nicotine Activity on Dopaminergic Neurons edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602". 

See also[edit]

References[edit]

  1. ^ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988. 
  2. ^ a b "Entrez Gene: CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.