GRID1

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Glutamate receptor, ionotropic, delta 1
Identifiers
Symbols GRID1 ; GluD1
External IDs OMIM610659 MGI95812 HomoloGene69017 IUPHAR: GluD1 ChEMBL: 2936 GeneCards: GRID1 Gene
RNA expression pattern
PBB GE GRID1 gnf1h05720 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2894 14803
Ensembl ENSG00000182771 ENSMUSG00000041078
UniProt Q9ULK0 Q61627
RefSeq (mRNA) NM_017551 NM_008166
RefSeq (protein) NP_060021 NP_032192
Location (UCSC) Chr 10:
87.36 – 88.13 Mb
Chr 14:
34.82 – 35.58 Mb
PubMed search [1] [2]

Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a protein[1][2] that in humans is encoded by the GRID1 gene.[3][4]

Function[edit]

This gene encodes a subunit of glutamate receptor ligand-gated ion channel. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[3]

Clinical significance[edit]

Several genetic epidemiology studies have shown a strong association between several variants of the GRID1 gene and increased risk of developing schizophrenia.[5][6]

See also[edit]

References[edit]

  1. ^ Yamazaki M, Araki K, Shibata A, Mishina M (March 1992). "Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family". Biochem. Biophys. Res. Commun. 183 (2): 886–92. doi:10.1016/0006-291X(92)90566-4. PMID 1372507. 
  2. ^ Treadaway J, Zuo J (December 1998). "Mapping of the mouse glutamate receptor delta1 subunit (Grid1) to chromosome 14". Genomics 54 (2): 359–60. doi:10.1006/geno.1998.5599. PMID 9828146. 
  3. ^ a b "Entrez Gene: GRID1 glutamate receptor, ionotropic, delta 1". 
  4. ^ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462. 
  5. ^ Guo SZ, Huang K, Shi YY, Tang W, Zhou J, Feng GY, Zhu SM, Liu HJ, Chen Y, Sun XD, He L (July 2007). "A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population". Schizophr. Res. 93 (1–3): 385–90. doi:10.1016/j.schres.2007.03.007. PMID 17490860. 
  6. ^ Treutlein J, Mühleisen TW, Frank J, Mattheisen M, Herms S, Ludwig KU, Treutlein T, Schmael C, Strohmaier J, Bösshenz KV, Breuer R, Paul T, Witt SH, Schulze TG, Schlösser RG, Nenadic I, Sauer H, Becker T, Maier W, Cichon S, Nöthen MM, Rietschel M (June 2009). "Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter". Schizophr. Res. 111 (1–3): 123–30. doi:10.1016/j.schres.2009.03.011. PMID 19346103. 

Further reading[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.