Gamma-aminobutyric acid receptor subunit alpha-1

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Gamma-aminobutyric acid (GABA) A receptor, alpha 1
Symbols GABRA1 ; ECA4; EIEE19; EJM; EJM5
External IDs OMIM137160 MGI95613 HomoloGene629 IUPHAR: α1 ChEMBL: 1962 GeneCards: GABRA1 Gene
RNA expression pattern
PBB GE GABRA1 206678 at tn.png
More reference expression data
Species Human Mouse
Entrez 2554 14394
Ensembl ENSG00000022355 ENSMUSG00000010803
UniProt P14867 P62812
RefSeq (mRNA) NM_000806 NM_010250
RefSeq (protein) NP_000797 NP_034380
Location (UCSC) Chr 5:
161.85 – 161.9 Mb
Chr 11:
42.13 – 42.18 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit alpha-1 is a protein that in humans is encoded by the GABRA1 gene.[1]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.[2]

See also[edit]


  1. ^ Johnson KJ, Sander T, Hicks AA, van Marle A, Janz D, Mullan MJ, Riley BP, Darlison MG (Dec 1992). "Confirmation of the localization of the human GABAA receptor alpha 1-subunit gene (GABRA1) to distal 5q by linkage analysis". Genomics 14 (3): 745–8. doi:10.1016/S0888-7543(05)80178-8. PMID 1330891. 
  2. ^ "Entrez Gene: GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.