Gamma-aminobutyric acid receptor subunit alpha-1

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Gamma-aminobutyric acid (GABA) A receptor, alpha 1
Identifiers
Symbols GABRA1 ; ECA4; EIEE19; EJM; EJM5
External IDs OMIM137160 MGI95613 HomoloGene629 IUPHAR: α1 ChEMBL: 1962 GeneCards: GABRA1 Gene
RNA expression pattern
PBB GE GABRA1 206678 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2554 14394
Ensembl ENSG00000022355 ENSMUSG00000010803
UniProt P14867 P62812
RefSeq (mRNA) NM_000806 NM_010250
RefSeq (protein) NP_000797 NP_034380
Location (UCSC) Chr 5:
161.85 – 161.9 Mb
Chr 11:
42.13 – 42.18 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit alpha-1 is a protein that in humans is encoded by the GABRA1 gene.[1]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.[2]

See also[edit]

References[edit]

  1. ^ Johnson KJ, Sander T, Hicks AA, van Marle A, Janz D, Mullan MJ, Riley BP, Darlison MG (Dec 1992). "Confirmation of the localization of the human GABAA receptor alpha 1-subunit gene (GABRA1) to distal 5q by linkage analysis". Genomics 14 (3): 745–8. doi:10.1016/S0888-7543(05)80178-8. PMID 1330891. 
  2. ^ "Entrez Gene: GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.