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Cholinergic receptor, nicotinic, delta (muscle)
External IDs OMIM100720 MGI87893 HomoloGene37340 IUPHAR: δ ChEMBL: 3011 GeneCards: CHRND Gene
RNA expression pattern
PBB GE CHRND 207024 at tn.png
More reference expression data
Species Human Mouse
Entrez 1144 11447
Ensembl ENSG00000135902 ENSMUSG00000026251
UniProt Q07001 P02716
RefSeq (mRNA) NM_000751 NM_021600
RefSeq (protein) NP_000742 NP_067611
Location (UCSC) Chr 2:
233.39 – 233.4 Mb
Chr 1:
87.19 – 87.2 Mb
PubMed search [1] [2]

Acetylcholine receptor subunit delta is a protein that in humans is encoded by the CHRND gene.[1]

The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.[1]


CHRND has been shown to interact with Cholinergic receptor, nicotinic, alpha 1.[2][3]

See also[edit]


  1. ^ a b "Entrez Gene: CHRND cholinergic receptor, nicotinic, delta". 
  2. ^ Kreienkamp, H J; Maeda R K; Sine S M; Taylor P (March 1995). "Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor". Neuron (UNITED STATES) 14 (3): 635–44. doi:10.1016/0896-6273(95)90320-8. ISSN 0896-6273. PMID 7695910. 
  3. ^ Wang, Z Z; Hardy S F; Hall Z W (November 1996). "Assembly of the nicotinic acetylcholine receptor. The first transmembrane domains of truncated alpha and delta subunits are required for heterodimer formation in vivo". J. Biol. Chem. (UNITED STATES) 271 (44): 27575–84. doi:10.1074/jbc.271.44.27575. ISSN 0021-9258. PMID 8910344. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.