GABRA4

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Gamma-aminobutyric acid (GABA) A receptor, alpha 4
Identifiers
Symbol GABRA4
External IDs OMIM137141 MGI95616 HomoloGene631 IUPHAR: α4 ChEMBL: 2472 GeneCards: GABRA4 Gene
RNA expression pattern
PBB GE GABRA4 208463 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2557 14397
Ensembl ENSG00000109158 ENSMUSG00000029211
UniProt P48169 Q9D6F4
RefSeq (mRNA) NM_000809 NM_010251
RefSeq (protein) NP_000800 NP_034381
Location (UCSC) Chr 4:
46.92 – 47 Mb
Chr 5:
71.57 – 71.66 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit alpha-4 is a protein that in humans is encoded by the GABRA4 gene.[1][2]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.[2]

See also[edit]

References[edit]

  1. ^ McLean PJ, Farb DH, Russek SJ (Aug 1995). "Mapping of the alpha 4 subunit gene (GABRA4) to human chromosome 4 defines an alpha 2-alpha 4-beta 1-gamma 1 gene cluster: further evidence that modern GABAA receptor gene clusters are derived from an ancestral cluster". Genomics 26 (3): 580–6. doi:10.1016/0888-7543(95)80178-O. PMID 7607683. 
  2. ^ a b "Entrez Gene: GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.