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Gamma-aminobutyric acid (GABA) A receptor, alpha 4
Symbol GABRA4
External IDs OMIM137141 MGI95616 HomoloGene631 IUPHAR: α4 ChEMBL: 2472 GeneCards: GABRA4 Gene
RNA expression pattern
PBB GE GABRA4 208463 at tn.png
More reference expression data
Species Human Mouse
Entrez 2557 14397
Ensembl ENSG00000109158 ENSMUSG00000029211
UniProt P48169 Q9D6F4
RefSeq (mRNA) NM_000809 NM_010251
RefSeq (protein) NP_000800 NP_034381
Location (UCSC) Chr 4:
46.92 – 47 Mb
Chr 5:
71.57 – 71.66 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit alpha-4 is a protein that in humans is encoded by the GABRA4 gene.[1][2]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.[2]

See also[edit]


  1. ^ McLean PJ, Farb DH, Russek SJ (Aug 1995). "Mapping of the alpha 4 subunit gene (GABRA4) to human chromosome 4 defines an alpha 2-alpha 4-beta 1-gamma 1 gene cluster: further evidence that modern GABAA receptor gene clusters are derived from an ancestral cluster". Genomics 26 (3): 580–6. doi:10.1016/0888-7543(95)80178-O. PMID 7607683. 
  2. ^ a b "Entrez Gene: GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.