GABRQ

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Gamma-aminobutyric acid (GABA) A receptor, theta
Identifiers
Symbols GABRQ ; THETA
External IDs OMIM300349 MGI1888498 HomoloGene10233 IUPHAR: θ ChEMBL: 2843 GeneCards: GABRQ Gene
Orthologs
Species Human Mouse
Entrez 55879 57249
Ensembl ENSG00000147402 ENSMUSG00000031344
UniProt Q9UN88 Q9JLF1
RefSeq (mRNA) NM_018558 NM_020488
RefSeq (protein) NP_061028 NP_065234
Location (UCSC) Chr X:
151.81 – 151.83 Mb
Chr X:
72.83 – 72.84 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit theta is a protein that in humans is encoded by theGABRQ gene.[1][2] The protein encoded by this gene is a subunit of the GABAA receptor.

The θ subunit has highest sequence similarity with the β1 subunit.[2] This subunit coassembles with:

  • α2, β1, and γ1[2]
  • α3 and β1[3]
  • α3, β1, and ε.[3]

References[edit]

  1. ^ Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER (15 May 2000). "GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus". J. Neurosci. 20 (10): 3588–95. PMID 10804200. 
  2. ^ a b c Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ (August 1999). "θ, a novel γ-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–6. doi:10.1073/pnas.96.17.9891. PMC 22306. PMID 10449790. 
  3. ^ a b Ranna M, Sinkkonen ST, Möykkynen T, Uusi-Oukari M, Korpi ER (2006). "Impact of ε and θ subunits on pharmacological properties of α3β1 GABAA receptors expressed in Xenopus oocytes". BMC Pharmacol. 6: 1. doi:10.1186/1471-2210-6-1. PMC 1363348. PMID 16412217. 

Further reading[edit]

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