GABRB2

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Gamma-aminobutyric acid (GABA) A receptor, beta 2
Identifiers
Symbols GABRB2 ; MGC119386; MGC119388; MGC119389
External IDs OMIM600232 MGI95620 HomoloGene7327 IUPHAR: β2 ChEMBL: 1920 GeneCards: GABRB2 Gene
RNA expression pattern
PBB GE GABRB2 207352 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2561 14401
Ensembl ENSG00000145864 ENSMUSG00000007653
UniProt P47870 P63137
RefSeq (mRNA) NM_000813 NM_008070
RefSeq (protein) NP_000804 NP_032096
Location (UCSC) Chr 5:
160.72 – 160.98 Mb
Chr 11:
42.42 – 42.63 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit beta-2 is a protein that in humans is encoded by the GABRB2 gene.[1][2]

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion.[2]

Interactions[edit]

GABRB2 has been shown to interact with TRAK2.[3]

See also[edit]

References[edit]

  1. ^ Russek SJ, Farb DH (Mar 1995). "Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform". Genomics 23 (3): 528–33. doi:10.1006/geno.1994.1539. PMID 7851879. 
  2. ^ a b "Entrez Gene: GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2". 
  3. ^ Beck, Mike; Brickley Kieran; Wilkinson Helen L; Sharma Seema; Smith Miriam; Chazot Paul L; Pollard Simon; Stephenson F Anne (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". J. Biol. Chem. (United States) 277 (33): 30079–90. doi:10.1074/jbc.M200438200. ISSN 0021-9258. PMID 12034717. 

Further reading[edit]

  • Moss SJ, Doherty CA, Huganir RL (1992). "Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor". J. Biol. Chem. 267 (20): 14470–6. PMID 1321150. 
  • Kellenberger S, Malherbe P, Sigel E (1993). "Function of the alpha 1 beta 2 gamma 2S gamma-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites". J. Biol. Chem. 267 (36): 25660–3. PMID 1334482. 
  • McKinley DD, Lennon DJ, Carter DB (1995). "Cloning, sequence analysis and expression of two forms of mRNA coding for the human beta 2 subunit of the GABAA receptor". Brain Res. Mol. Brain Res. 28 (1): 175–9. doi:10.1016/0169-328X(94)00228-7. PMID 7707873. 
  • Tögel M, Mossier B, Fuchs K, Sieghart W (1994). "gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties". J. Biol. Chem. 269 (17): 12993–8. PMID 8175718. 
  • Hadingham KL, Wingrove PB, Wafford KA et al. (1994). "Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors". Mol. Pharmacol. 44 (6): 1211–8. PMID 8264558. 
  • Akbarian S, Huntsman MM, Kim JJ et al. (1996). "GABAA receptor subunit gene expression in human prefrontal cortex: comparison of schizophrenics and controls". Cereb. Cortex 5 (6): 550–60. doi:10.1093/cercor/5.6.550. PMID 8590827. 
  • Longson D, Longson CM, Jones EG (1997). "Localization of CAM II kinase-alpha, GAD, GluR2 and GABA(A) receptor subunit mRNAs in the human entorhinal cortex". Eur. J. Neurosci. 9 (4): 662–75. doi:10.1111/j.1460-9568.1997.tb01415.x. PMID 9153573. 
  • Russek SJ (1999). "Evolution of GABA(A) receptor diversity in the human genome". Gene 227 (2): 213–22. doi:10.1016/S0378-1119(98)00594-0. PMID 10023064. 
  • Bonnert TP, McKernan RM, Farrar S et al. (1999). "theta, a novel gamma-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–6. doi:10.1073/pnas.96.17.9891. PMC 22306. PMID 10449790. 
  • Brooks-Kayal AR, Shumate MD, Jin H et al. (1999). "Human neuronal gamma-aminobutyric acid(A) receptors: coordinated subunit mRNA expression and functional correlates in individual dentate granule cells". J. Neurosci. 19 (19): 8312–8. PMID 10493732. 
  • Buckley ST, Eckert AL, Dodd PR (2006). "Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex". Ann. N. Y. Acad. Sci. 914: 58–64. doi:10.1111/j.1749-6632.2000.tb05183.x. PMID 11085308. 
  • Salim K, Fenton T, Bacha J et al. (2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation". J. Biol. Chem. 277 (18): 15482–5. doi:10.1074/jbc.M201539200. PMID 11854302. 
  • Beck M, Brickley K, Wilkinson HL et al. (2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". J. Biol. Chem. 277 (33): 30079–90. doi:10.1074/jbc.M200438200. PMID 12034717. 
  • Iyer SP, Akimoto Y, Hart GW (2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase". J. Biol. Chem. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Wang J, Liu S, Haditsch U et al. (2003). "Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapses". J. Neurosci. 23 (3): 826–36. PMID 12574411. 
  • Pirker S, Schwarzer C, Czech T et al. (2003). "Increased expression of GABA(A) receptor beta-subunits in the hippocampus of patients with temporal lobe epilepsy". J. Neuropathol. Exp. Neurol. 62 (8): 820–34. PMID 14503638. 
  • Mercik K, Pytel M, Mozrzymas JW (2004). "Recombinant alpha 1 beta 2 gamma 2 GABA(A) receptors expressed in HEK293 and in QT6 cells show different kinetics". Neurosci. Lett. 352 (3): 195–8. doi:10.1016/j.neulet.2003.08.060. PMID 14625018. 
  • Lo WS, Lau CF, Xuan Z et al. (2005). "Association of SNPs and haplotypes in GABAA receptor beta2 gene with schizophrenia". Mol. Psychiatry 9 (6): 603–8. doi:10.1038/sj.mp.4001461. PMID 14699426. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.