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Glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Protein GRIN2B PDB 1S11.png
Rendering based on PDB 1S11.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GRIN2B ; GluN2B; MRD6; NMDAR2B; NR2B; hNR3
External IDs OMIM138252 MGI95821 HomoloGene646 IUPHAR: GluN2B ChEMBL: 1904 GeneCards: GRIN2B Gene
RNA expression pattern
PBB GE GRIN2B 210412 at tn.png
PBB GE GRIN2B 210411 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2904 14812
Ensembl ENSG00000273079 ENSMUSG00000030209
UniProt Q13224 Q01097
RefSeq (mRNA) NM_000834 NM_008171
RefSeq (protein) NP_000825 NP_032197
Location (UCSC) Chr 12:
13.69 – 14.13 Mb
Chr 6:
135.71 – 136.17 Mb
PubMed search [1] [2]

Glutamate [NMDA] receptor subunit epsilon-2 also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B) is a protein that in humans is encoded by the GRIN2B gene.[1]


N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.[2]


  • Besonprodil
  • CERC-301 selective NR2B receptor antagonist
  • Eliprodil
  • Evt 101, a selective NR2B receptor antagonist, is being tested as a potentially fast acting antidepressant.[3]
  • Ro-25-6981 (also known as MI-4) - selective NR2B receptor antagonist
  • Traxoprodil selective NR2B receptor antagonist


GRIN2B has been shown to interact with:

See also[edit]


  1. ^ Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H et al. (Jun 1992). "Heteromeric NMDA receptors: molecular and functional distinction of subtypes". Science 256 (5060): 1217–21. doi:10.1126/science.256.5060.1217. PMID 1350383. 
  2. ^ "Entrez Gene: GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B". 
  3. ^ "The Effects of a Novel NMDA NR2B-Subtype Selective Antagonist, EVT 101, on Brain Function". NCT00526968. 2008-02-14. Retrieved 2010-08-19. 
  4. ^ Wyszynski M, Lin J, Rao A, Nigh E, Beggs A, Craig A et al. (January 1997). "Competitive binding of alpha-actinin and calmodulin to the NMDA receptor". Nature 385 (6615): 439–42. doi:10.1038/385439a0. PMID 9009191. 
  5. ^ a b c Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y (June 2002). "Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses". Am. J. Physiol., Cell Physiol. 282 (6): C1396–403. doi:10.1152/ajpcell.00615.2001. PMID 11997254. 
  6. ^ a b c Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K et al. (September 1997). "Binding of neuroligins to PSD-95". Science 277 (5331): 1511–5. PMID 9278515. 
  7. ^ a b c Sans N, Prybylowski K, Petralia R, Chang K, Wang Y, Racca C et al. (June 2003). "NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex". Nat. Cell Biol. 5 (6): 520–30. doi:10.1038/ncb990. PMID 12738960. 
  8. ^ a b Lim I, Hall D, Hell J (June 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. 277 (24): 21697–711. doi:10.1074/jbc.M112339200. PMID 11937501. 
  9. ^ Niethammer M, Valtschanoff J, Kapoor T, Allison D, Weinberg R, Craig A et al. (April 1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron 20 (4): 693–707. PMID 9581762. 
  10. ^ Kornau H, Schenker L, Kennedy M, Seeburg P (September 1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science 269 (5231): 1737–40. PMID 7569905. 
  11. ^ Jo K, Derin R, Li M, Bredt D (June 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J. Neurosci. 19 (11): 4189–99. PMID 10341223. 
  12. ^ Nakazawa T, Watabe A, Tezuka T, Yoshida Y, Yokoyama K, Umemori H et al. (July 2003). "p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling". Mol. Biol. Cell 14 (7): 2921–34. doi:10.1091/mbc.E02-09-0623. PMC 165687. PMID 12857875. 

Further reading[edit]

  • Schröder H, Perovic S, Kavsan V, Ushijima H, Müller W (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology 19 (4-5): 683–8. PMID 9745929. 
  • Nagy J (2004). "The NR2B subtype of NMDA receptor: a potential target for the treatment of alcohol dependence". Curr Drug Targets CNS Neurol Disord 3 (3): 169–79. doi:10.2174/1568007043337409. PMID 15180478. 
  • King J, Eugenin E, Buckner C, Berman J (2006). "HIV tat and neurotoxicity". Microbes Infect. 8 (5): 1347–57. doi:10.1016/j.micinf.2005.11.014. PMID 16697675. 
  • Kornau H, Schenker L, Kennedy M, Seeburg P (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science 269 (5231): 1737–40. doi:10.1126/science.7569905. PMID 7569905. 
  • Magnuson D, Knudsen B, Geiger J, Brownstone R, Nath A (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity". Ann. Neurol. 37 (3): 373–80. doi:10.1002/ana.410370314. PMID 7695237. 
  • Mandich P, Schito A, Bellone E, Antonacci R, Finelli P, Rocchi M et al. (1994). "Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12". Genomics 22 (1): 216–8. doi:10.1006/geno.1994.1366. PMID 7959773. 
  • Adams S, Foldes R, Kamboj R (1995). "Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein". Biochim. Biophys. Acta 1260 (1): 105–8. doi:10.1016/0167-4781(94)00189-a. PMID 7999784. 
  • Sheng M, Cummings J, Roldan L, Jan Y, Jan L (1994). "Changing subunit composition of heteromeric NMDA receptors during development of rat cortex". Nature 368 (6467): 144–7. doi:10.1038/368144a0. PMID 8139656. 
  • Roche K, Raymond L, Blackstone C, Huganir R (1994). "Transmembrane topology of the glutamate receptor subunit GluR6". J. Biol. Chem. 269 (16): 11679–82. PMID 8163463. 
  • Lannuzel A, Lledo P, Lamghitnia H, Vincent J, Tardieu M (1995). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". Eur. J. Neurosci. 7 (11): 2285–93. doi:10.1111/j.1460-9568.1995.tb00649.x. PMID 8563977. 
  • Corasaniti M, Melino G, Navarra M, Garaci E, Finazzi-Agrò A, Nisticò G (1995). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration 4 (3): 315–21. doi:10.1016/1055-8330(95)90021-7. PMID 8581564. 
  • Niethammer M, Kim E, Sheng M (1996). "Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases". J. Neurosci. 16 (7): 2157–63. PMID 8601796. 
  • Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120". AIDS 10 (5): 463–8. doi:10.1097/00002030-199605000-00003. PMID 8724036. 
  • Hess S, Daggett L, Crona J, Deal C, Lu C, Urrutia A et al. (1996). "Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors". J. Pharmacol. Exp. Ther. 278 (2): 808–16. PMID 8768735. 
  • Müller B, Kistner U, Kindler S, Chung W, Kuhlendahl S, Fenster S et al. (1996). "SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo". Neuron 17 (2): 255–65. doi:10.1016/S0896-6273(00)80157-9. PMID 8780649. 
  • Wu P, Price P, Du B, Hatch W, Terwilliger E (1996). "Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons". Neuroreport 7 (5): 1045–9. doi:10.1097/00001756-199604100-00018. PMID 8804048. 
  • Bennett B, Rusyniak D, Hollingsworth C (1995). "HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures". Brain Res. 705 (1-2): 168–76. doi:10.1016/0006-8993(95)01166-8. PMID 8821747. 
  • Toggas S, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine". Brain Res. 706 (2): 303–7. doi:10.1016/0006-8993(95)01197-8. PMID 8822372. 
  • Dreyer E, Lipton S (1995). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid". Eur. J. Neurosci. 7 (12): 2502–7. doi:10.1111/j.1460-9568.1995.tb01048.x. PMID 8845955. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.