GABRD

Gamma-aminobutyric acid (GABA) A receptor, delta
Identifiers
Symbols	GABRD; EIG10; EJM7; GEFSP5; MGC45284
External IDs	OMIM: 137163 MGI: 95622 HomoloGene: 55489 IUPHAR: δ GeneCards: GABRD Gene
Gene Ontology Molecular function • GABA-A receptor activity • ion channel activity • extracellular ligand-gated ion channel activity • chloride channel activity Cellular component • plasma membrane • integral to plasma membrane • cell junction • chloride channel complex • synapse • postsynaptic membrane Biological process • transport • ion transport • signal transduction • synaptic transmission Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2563	14403
Ensembl	ENSG00000187730	ENSMUSG00000029054
UniProt	O14764	Q14AH9
RefSeq (mRNA)	NM_000815	NM_008072.2
RefSeq (protein)	NP_000806	NP_032098.2
Location (UCSC)	Chr 1: 1.95 – 1.96 Mb	Chr 4: 154.76 – 154.77 Mb
PubMed search	[1]	[2]

Gamma-aminobutyric acid receptor subunit delta is a protein that in humans is encoded by the GABRD gene.

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit.

See also

• GABAA receptor

Further reading

• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Lenzen KP, Heils A, Lorenz S, et al. (2005). "Association analysis of the Arg220His variation of the human gene encoding the GABA delta subunit with idiopathic generalized epilepsy.". Epilepsy Res. 65 (1-2): 53–7. doi:10.1016/j.eplepsyres.2005.04.005. PMID 16023832. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Windpassinger C, Kroisel PM, Wagner K, Petek E (2002). "The human gamma-aminobutyric acid A receptor delta (GABRD) gene: molecular characterisation and tissue-specific expression.". Gene 292 (1-2): 25–31. doi:10.1016/S0378-1119(02)00649-2. PMID 12119096. 

External links

• MeSH GABRD+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.