From Wikipedia, the free encyclopedia
Jump to: navigation, search
Gamma-aminobutyric acid (GABA) A receptor, alpha 6
Symbols GABRA6 ; MGC116903; MGC116904
External IDs OMIM137143 MGI95618 HomoloGene20220 IUPHAR: 409 ChEMBL: 2579 GeneCards: GABRA6 Gene
RNA expression pattern
PBB GE GABRA6 207182 at tn.png
More reference expression data
Species Human Mouse
Entrez 2559 14399
Ensembl ENSG00000145863 ENSMUSG00000020428
UniProt Q16445 P16305
RefSeq (mRNA) NM_000811 NM_001099641
RefSeq (protein) NP_000802 NP_001093111
Location (UCSC) Chr 5:
160.97 – 161.13 Mb
Chr 11:
42.31 – 42.32 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit alpha-6 is a protein that in humans is encoded by the GABRA6 gene.[1][2]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.[2]

One study has found a genetic variant in the gene to be associated with the personality trait neuroticism.[3]

See also[edit]


  1. ^ Hicks AA, Bailey ME, Riley BP, Kamphuis W, Siciliano MJ, Johnson KJ, Darlison MG (Aug 1994). "Further evidence for clustering of human GABAA receptor subunit genes: localization of the alpha 6-subunit gene (GABRA6) to distal chromosome 5q by linkage analysis". Genomics 20 (2): 285–8. doi:10.1006/geno.1994.1167. PMID 8020978. 
  2. ^ a b "Entrez Gene: GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6". 
  3. ^ Srijan Sen, Sandra Villafuerte, Randolph Nesse, Scott F. Stoltenberg, Jeffrey Hopcian, Lillian Gleiberman, Alan Weder & Margit Burmeister (February 2004). "Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism". Biological Psychiatry 55 (3): 244–249. doi:10.1016/j.biopsych.2003.08.006. PMID 14744464. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.