P2RX5

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Purinergic receptor P2X, ligand-gated ion channel, 5
Identifiers
Symbols P2RX5 ; LRH-1; P2X5; P2X5R
External IDs OMIM602836 MGI2137026 HomoloGene1924 IUPHAR: P2X5 ChEMBL: 4942 GeneCards: P2RX5 Gene
Orthologs
Species Human Mouse
Entrez 5026 94045
Ensembl ENSG00000083454 ENSMUSG00000005950
UniProt Q93086 B1AUD6
RefSeq (mRNA) NM_001204519 NM_033321
RefSeq (protein) NP_001191448 NP_201578
Location (UCSC) Chr 17:
3.58 – 3.6 Mb
Chr 11:
73.16 – 73.17 Mb
PubMed search [1] [2]

P2X purinoceptor 5 is a protein that in humans is encoded by the P2RX5 gene.[1][2]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Four transcript variants encoding distinct isoforms have been identified for this gene.[2]

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References[edit]

  1. ^ Le KT, Paquet M, Nouel D, Babinski K, Seguela P (Jan 1998). "Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system". FEBS Lett 418 (1–2): 195–9. doi:10.1016/S0014-5793(97)01380-X. PMID 9414125. 
  2. ^ a b "Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5". 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.