Cefditoren

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Cefditoren
Cefditoren.svg
Systematic (IUPAC) name
(7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((Z)-2-(4-methylthiazol-5-yl)vinyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
Trade names Spectracef
AHFS/Drugs.com monograph
MedlinePlus a605003
Legal status ?
Identifiers
CAS number 104145-95-1 N
ATC code J01DD16
PubChem CID 9870843
DrugBank DB01066
ChemSpider 8046534 YesY
UNII 81QS09V3YW YesY
KEGG D07639 N
ChEBI CHEBI:59343 YesY
ChEMBL CHEMBL610374 N
Chemical data
Formula C19H18N6O5S3 
Mol. mass 506.58 g/mol
 N (what is this?)  (verify)

Cefditoren is a third-generation cephalosporin antibiotic for oral use. It is commonly marketed under the trade name Spectracef by Vansen Pharma Inc.

Cefditoren is also marketed under the name Meiact by Meiji Seika Pharma Co., Ltd.[1]

Spectrum of bacterial susceptibility[edit]

Cefditoren has a broad spectrum of activity and has been used to treat bacterial infections of the skin and respiratory tract, including bronchitis, pneumonia, and tonsillitis. The following represents MIC susceptibility data for a few medically significant microorganisms.

  • Haemophilus influenzae: ≥0.063 - 0.25 μg/ml
  • Staphylcoccus aureus: 0.25 - >128 μg/ml (includes MRSA)
  • Streptococcus pyogenes: ≤0.004 - 2 μg/ml[2]

Cefditoren is a broad-spectrum against Gram-negative and Gram-positive bacteria, but is only effective for anaerobic bacteria and cannot be used against Pseudomonas aeruginosa, which is aerobic.[3]

Clinical use[edit]

Main article: Cephalosporin

Indications[edit]

Cefditoren is used to treat uncomplicated skin and skin structure infections, community-acquired pneumonia, acute bacterial exacerbation of chronic bronchitis, pharyngitis, and tonsillitis.

Formulations[edit]

Cefditoren is available as 200- and 400-mg tablets. It can be formulated as the prodrug cefditoren pivoxil.

Chemical structure of cefditoren pivoxil

References[edit]

External links[edit]